Silencing of MEG3 inhibited ox‐LDL‐induced inflammation and apoptosis in macrophages via modulation of the MEG3/miR‐204/CDKN2A regulatory axis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11105
Abstract: Atherosclerosis (AS) is one of the most common chronic inflammatory diseases and a major cause of morbidity and mortality. However, the underlying molecular mechanisms of the progression of AS are still largely unknown. Increasing evidence… read more here.
Keywords: meg3; cells treated; cdkn2a; mir 204 ... See more keywords
Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3153
Abstract: Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship that may in part be mediated through altered epigenetic regulation of genes. We previously identified a region… read more here.
Keywords: methylation; cdkn2a; bone; bone mass ... See more keywords
Hhex Regulates Hematopoietic Stem Cell Self‐Renewal and Stress Hematopoiesis via Repression of Cdkn2a
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2648
Abstract: The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic progenitors and B‐cells during development. We have recently shown that in adult hematopoiesis, Hhex is dispensable for maintenance of hematopoietic… read more here.
Keywords: hematopoiesis; cdkn2a; self renewal; hematopoietic stem ... See more keywords
CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02169-z
Abstract: Pediatric supratentorial ependymomas with RELA fusions (RELA-EP) have been identified as a unique novel tumor entity [9, 10]. Fusions between C11orf95 and RELA pathologically activate the NFκB signaling pathway indicated by nuclear accumulation of p65-RelA.… read more here.
Keywords: rela; p16 protein; cdkn2a deletion; cdkn2a ... See more keywords
Methyltransferase Inhibition Enables Tgfβ Driven Induction of CDKN2A and B in Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2023.2186074
Abstract: Abstract CDKN2A/B deletion or silencing is common across human cancer, reinforcing the general importance of bypassing its tumor suppression in cancer formation or progression. In rhabdomyosarcoma (RMS) and neuroblastoma, two common childhood cancers, the three… read more here.
Keywords: cdkn2a; methyltransferase inhibition; tgf; cancer ... See more keywords
Molecular profiling of primary uveal melanoma: results of a Polish cohort
Sign Up to like & getrecommendations! Published in 2023 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000874
Abstract: There is no published data regarding the molecular alterations of Polish patients with primary uveal melanoma. We performed whole exome sequencing of 20 primary uveal melanomas (UMs), 10 metastasizing and 10 non-metastasizing cases to identify… read more here.
Keywords: primary uveal; loss; mutation; cdkn2a ... See more keywords
Comprehensive analyses of cuproptosis-related gene CDKN2A on prognosis and immunologic therapy in human tumors
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000033468
Abstract: Recent studies have identified a novel programmed cell death based on copper, named cuproptosis. However, as an anti-cuproptosis gene, the functional roles, definite mechanisms and prognostic value of CDKN2A in pan-cancer are largely unclear. The… read more here.
Keywords: cuproptosis; cdkn2a; expression; analysis ... See more keywords
Frequent homozygous deletion of Cdkn2a/2b in tremolite‐induced malignant mesothelioma in rats
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14358
Abstract: The onset of malignant mesothelioma (MM) is linked to exposure to asbestos fibers. Asbestos fibers are classified as serpentine (chrysotile) or amphibole, which includes the crocidolite, amosite, anthophyllite, tremolite, and actinolite types. Although few studies… read more here.
Keywords: tremolite; cdkn2a; microscopy; homozygous deletion ... See more keywords
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosome Repairs Endometrial Epithelial Cells Injury Induced by Hypoxia via Regulating miR-663a/CDKN2A Axis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3082969
Abstract: Aim Thin endometrium remains a severe clinical challenge with no effective therapy to date. We aimed at exploring the role and molecular mechanism of human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-Ex) in… read more here.
Keywords: cell; hucmsc; mir 663a; expression ... See more keywords
Identification of De Novo Enhancers Activated by TGFβ to Drive Expression of CDKN2A and B in HeLa Cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0289
Abstract: Disruption of the CDKN2A (INK4A/ARF) and B (INK4B) genes, which encode three function-independent tumor suppressors, is one of the most common events in human cancer. Because their relative importance in tumor prevention appears to be… read more here.
Keywords: expression; arf; tgf; hela cells ... See more keywords
MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018027672
Abstract: The genetic alterations that define primary central nervous system lymphoma (PCNSL) are incompletely elucidated, and the genomic evolution from diagnosis to relapse is poorly understood. We performed whole-exome sequencing (WES) on 36 PCNSL patients and… read more here.
Keywords: cdkn2a; nervous system; central nervous; primary central ... See more keywords