CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02169-z
Abstract: Pediatric supratentorial ependymomas with RELA fusions (RELA-EP) have been identified as a unique novel tumor entity [9, 10]. Fusions between C11orf95 and RELA pathologically activate the NFκB signaling pathway indicated by nuclear accumulation of p65-RelA.… read more here.
Keywords: rela; p16 protein; cdkn2a deletion; cdkn2a ... See more keywords
Association of CDKN2A/2B deletion with homozygous deletion of TCR- γ gene in T-ALL.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e18516
Abstract: e18516Background: T-lineage acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations. Absenc... read more here.
Keywords: cdkn2a deletion; deletion tcr; deletion; homozygous deletion ... See more keywords
Role of CDKN2A deletion in grade 2/3 IDH-mutant astrocytomas: need for selective approach in resource-constrained settings.
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgical focus"
DOI: 10.3171/2022.9.focus22427
Abstract: OBJECTIVE The authors aimed to assess the frequency of homozygous CDKN2A deletion in isocitrate dehydrogenase (IDH)-mutant diffuse astrocytomas (grade 2/3) and to narrow down the clinicopathological indications in which the CDKN2A fluorescence in situ hybridization… read more here.
Keywords: idh mutant; grade; deletion; resource constrained ... See more keywords
Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study
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DOI: 10.3390/diagnostics10060386
Abstract: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with a poor survival. Although some advances in knowledge have been obtained for the pleural form, much less is known about DMPM. Advantages in terms… read more here.
Keywords: deletion; expression p16; cdkn2a deletion; ki67 ... See more keywords