CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02169-z
Abstract: Pediatric supratentorial ependymomas with RELA fusions (RELA-EP) have been identified as a unique novel tumor entity [9, 10]. Fusions between C11orf95 and RELA pathologically activate the NFκB signaling pathway indicated by nuclear accumulation of p65-RelA.… read more here.
Keywords: rela; p16 protein; cdkn2a deletion; cdkn2a ... See more keywords
A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-024-04852-7
Abstract: Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated with a younger age at diagnosis and better prognosis than IDH wild-type glioblastoma. Within IDH mutant gliomas,… read more here.
Keywords: idh mutant; deletion; gliomas; cdkn2a deletion ... See more keywords
PATH-52. Understanding the prevalence of MTAP and CDKN2A/B deletion in gliomas by next generation sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1004
Abstract: CDKN2A/B (cyclin-dependent kinase inhibitor 2A/B) gene alterations are integral to the diagnosis and prognostication of IDH-mutant gliomas. CDKN2A/B status is commonly assessed by next generation sequencing (NGS) or inferred from loss of the surrogate marker… read more here.
Keywords: deletion; next generation; cdkn2a deletion; mtap deletion ... See more keywords
Abstract 6633: Survival implications of CDKN2A/2B deletion, MET amplification and PIK3R1 mutation in adult type diffuse glioma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6633
Abstract: Diffuse gliomas, the most common primary brain tumors, present significant variations in morphology, location, genetic alterations, and treatment responses. However, the relationship between their molecular profiles and disease outcomes remains poorly understood. This study analyzed… read more here.
Keywords: deletion; cdkn2a deletion; diffuse; amplification ... See more keywords
Association of CDKN2A/2B deletion with homozygous deletion of TCR- γ gene in T-ALL.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e18516
Abstract: e18516Background: T-lineage acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations. Absenc... read more here.
Keywords: cdkn2a deletion; deletion tcr; deletion; homozygous deletion ... See more keywords
Role of CDKN2A deletion in grade 2/3 IDH-mutant astrocytomas: need for selective approach in resource-constrained settings.
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgical focus"
DOI: 10.3171/2022.9.focus22427
Abstract: OBJECTIVE The authors aimed to assess the frequency of homozygous CDKN2A deletion in isocitrate dehydrogenase (IDH)-mutant diffuse astrocytomas (grade 2/3) and to narrow down the clinicopathological indications in which the CDKN2A fluorescence in situ hybridization… read more here.
Keywords: idh mutant; grade; deletion; resource constrained ... See more keywords
Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostics"
DOI: 10.3390/diagnostics10060386
Abstract: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with a poor survival. Although some advances in knowledge have been obtained for the pleural form, much less is known about DMPM. Advantages in terms… read more here.
Keywords: deletion; expression p16; cdkn2a deletion; ki67 ... See more keywords