Cost‐effectiveness of pancreas surveillance: The CDKN2A‐p16‐Leiden cohort
Sign Up to like & getrecommendations! Published in 2023 at "United European Gastroenterology Journal"
DOI: 10.1002/ueg2.12360
Abstract: Abstract Background CDKN2A‐p16‐Leiden mutation carriers have a high lifetime risk of developing pancreatic ductal adenocarcinoma (PDAC), with very poor survival. Surveillance may improve prognosis. Objective To assess the cost‐effectiveness of surveillance, as compared to no… read more here.
Keywords: cdkn2a p16; surveillance; cost; cost effectiveness ... See more keywords
Abstract 24: Oncogenic KrasG12D and Cdkn2a/p16 knockout in LGR5 expressing progenitor cells synergize to advance adenoma and adenocarcinoma phenotypes in murine small intestine
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-24
Abstract: Background: KRAS activating mutations are reported in 42-54% and inactivation of CDKN2A/p16 in 14-30% of human small intestinal adenocarcinomas, suggesting a role in small intestine adenocarcinogenesis. The phenotypic effects of oncogenic KRAS and p16 loss… read more here.
Keywords: krasg12d; cdkn2a p16; small intestine; progenitor cells ... See more keywords
Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence
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DOI: 10.3892/mmr.2022.12861
Abstract: Cell senescence is a state of limited cell proliferation during a stress response or as part of a programmed process. When a senescent cell stops dividing, maintaining metabolic activity contributes to cellular homeostasis maintenance. In… read more here.
Keywords: cdkn2a p16; cell; p16; senescence ... See more keywords