Palladium-mediated synthesis of 1,1,2-triarylethanes. Application to the synthesis of CDP-840
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DOI: 10.1016/j.tet.2017.01.030
Abstract: Abstract A three-step protocol toward 1,1,2-triarylethanes 1 starting with β-ketosulfones 2 is developed. A facile process is carried out for the (1) reduction of 2 with NaBH4, (2) BF3·OEt2-mediated Friedel-Crafts reactions of the resulting β-hydroxy… read more here.
Keywords: synthesis cdp; cdp 840; palladium mediated; mediated synthesis ... See more keywords