High-level living Cell Production of cytidine-5'-diphosphocholine in Metabolically Engineered Yeast.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2021.08.013
Abstract: Industrial production of neuroprotective drug CDP-choline is accomplished via permeabilized or lysed cell biotransformation because of the inefficient penetration of substrates into intact cells. We previously proposed a novel one-step living cell method for CDP-choline… read more here.
Keywords: cell; cdp choline; production; molar yield ... See more keywords
Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.09.006
Abstract: BACKGROUND Cytidine-5'-diphosphate choline (CDP-choline) has been suggested to exert neuroprotective and neuroreparative effects and may be beneficial for patients with stimulant dependence. This randomized, double-blind, placebo-controlled study in methamphetamine (MA) dependence investigated effects of CDP-choline… read more here.
Keywords: choline; cdp choline; randomized double; placebo ... See more keywords
Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally - Induced endotoxic shock.
Sign Up to like & getrecommendations! Published in 2021 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2021.10.010
Abstract: Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5'-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study… read more here.
Keywords: choline; cdp choline; endotoxin; choline cdp ... See more keywords
Impact of cytidine diphosphocholine on oxygenation in client‐owned dogs with aspiration pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16434
Abstract: Abstract Background New drugs for veterinary patients with acute respiratory distress syndrome (ARDS) are urgently needed. Early or late postinfection treatment of influenza‐infected mice with the liponucleotide cytidine diphosphocholine (CDP‐choline) resulted in decreased hypoxemia, pulmonary… read more here.
Keywords: choline; cytidine diphosphocholine; cdp choline; aspiration pneumonia ... See more keywords
CDP-choline Corrects Alveolar Type II Cell Mitochondrial Dysfunction in Influenza-infected Mice.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0512oc
Abstract: Development of ARDS in influenza A virus (IAV)-infected mice is associated with inhibition of alveolar type II (ATII) epithelial cell de novo phosphatidylcholine synthesis and administration of the phosphatidylcholine precursor CDP-choline attenuates IAV-induced ARDS in… read more here.
Keywords: cdp choline; cell; cell mitochondrial; synthesis ... See more keywords
Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0096ed
Abstract: Host-mediated immunopathology is a common feature of respiratory viral pathogens, including influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For this reason, targeting of immune dysregulation that mediates lung injury is an attractive proposition… read more here.
Keywords: choline; cdp choline; infection; alveolar type ... See more keywords
Assessing the acute effects of CDP-choline on sensory gating in schizophrenia: A pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881117746903
Abstract: Deficient sensory gating (SG) in schizophrenia is associated with functional outcome and offers a therapeutic target as it is linked to the altered function/expression of the α7 nicotinic acetylcholine receptors (nAChRs). This study analyzed the… read more here.
Keywords: sensory gating; gating schizophrenia; cdp choline; effects cdp ... See more keywords