Hydride Transfer Mechanism of Enzymatic Sugar Nucleotide C2 Epimerization Probed with a Loose-Fit CDP-Glucose Substrate
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DOI: 10.1021/acscatal.2c00257
Abstract: Transient oxidation–reduction through hydride transfer with tightly bound NAD coenzyme is used by a large class of sugar nucleotide epimerases to promote configurational inversion of carbon stereocenters in carbohydrate substrates. A requirement for the epimerases… read more here.
Keywords: hydride transfer; hydride; substrate; cdp glucose ... See more keywords