Transitions of CDR-L3 Loop Canonical Cluster Conformations on the Micro-to-Millisecond Timescale
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02652
Abstract: Sequence and structural diversity of antibodies are concentrated on six hypervariable loops, also known as the complementarity determining regions (CDRs). Five of six antibody CDR loops presumably adopt a so-called canonical structure out of a… read more here.
Keywords: cdr loop; transitions cdr; loop canonical; canonical cluster ... See more keywords
Accurate prediction of CDR-H3 loop structures of antibodies with deep learning
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.91512
Abstract: Accurate prediction of the structurally diverse complementarity determining region heavy chain 3 (CDR-H3) loop structure remains a primary and long-standing challenge for antibody modeling. Here, we present the H3-OPT toolkit for predicting the 3D structures… read more here.
Keywords: cdr loop; accurate prediction; loop structures; prediction ... See more keywords