Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump CDR1
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DOI: 10.1128/aac.00968-18
Abstract: Farnesol, a quorum-sensing molecule, inhibits Candida albicans hyphal formation, affects its biofilm formation and dispersal, and impacts its stress response. Several aspects of farnesol's mechanism of action remain incompletely uncharacterized. ABSTRACT Farnesol, a quorum-sensing molecule,… read more here.
Keywords: tac1 znc1; cluster transcription; candida albicans; cdr1 ... See more keywords
Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes
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DOI: 10.3390/jof8080783
Abstract: Candida auris is considered a serious fungal pathogen frequently exhibiting a high resistance to a wide range of antifungals. In this study, a combination of the quorum-sensing molecule farnesol (FAR) and fluconazole (FLU) was tested… read more here.
Keywords: candida auris; effect; auris; resistance ... See more keywords
Photodynamic Inactivation Effectively Eradicates Candida auris Biofilm despite Its Interference with the Upregulation of CDR1 and MDR1 Efflux Genes
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DOI: 10.3390/jof8111137
Abstract: Candida auris, in recent years, has emerged as a dangerous nosocomial pathogen. It represents a challenge for effective treatment because of its multiresistance. Photodynamic inactivation (PDI) is a promising way to solve problems with a… read more here.
Keywords: candida auris; auris; pdi; cdr1 ... See more keywords