Contribution of Clinically Derived Mutations in the Gene Encoding the Zinc Cluster Transcription Factor Mrr2 to Fluconazole Antifungal Resistance and CDR1 Expression in Candida albicans
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DOI: 10.1128/aac.00078-19
Abstract: Mutations in genes encoding zinc cluster transcription factors (ZCFs) such as TAC1, MRR1, and UPC2 play a key role in Candida albicans azole antifungal resistance. Artificial activation of the ZCF Mrr2 has shown increased expression… read more here.
Keywords: expression; encoding zinc; resistance; zinc cluster ... See more keywords
TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression
Sign Up to like & getrecommendations! Published in 2024 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01508-24
Abstract: ABSTRACT Candida auris is an emerging pathogenic fungus that is highly resistant to existing antifungal drugs. Manogepix is a novel antifungal agent that exerts antifungal activity by inhibiting glycosylphosphatidylinositol anchor biosynthesis. Although the mechanisms of… read more here.
Keywords: susceptibility; candida; cdr1 expression; mutation ... See more keywords