Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25641
Abstract: Minimal residual disease (MRD) tracking, by next generation sequencing of immunoglobulin sequences, is moving towards clinical implementation in multiple myeloma. However, there is only sparse information available to address whether clonal sequences remain stable for… read more here.
Keywords: cdr3 sequences; mrd tracking; multiple myeloma; light chain ... See more keywords
Age‐associated B cells expanded in autoimmune mice are memory cells sharing H‐CDR3‐selected repertoires
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747127
Abstract: Age‐associated B cells (ABCs) represent a distinct cell population expressing low levels of CD21 (CD21−/low). The Ig repertoire expressed by ABCs in aged mice is diverse and exhibits signs of somatic hypermutation (SHM). A CD21−/low… read more here.
Keywords: autoimmune mice; expanded autoimmune; associated cells; age associated ... See more keywords
A pilot study to assess peripheral blood TCR β-chain CDR3 repertoire in occupational medicamentosa-like dermatitis due to trichloroethylene using high-throughput sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2019.103211
Abstract: We exploratively characterized T cell receptor (TCR) repertoires from occupational medicamentosa-like dermatitis due to trichloroethylene (OMDT) patients to better understand the underlying pathological mechanism. We used a combination of multiplex-PCR, Illumina sequencing and IMGT/High V-QUEST… read more here.
Keywords: dermatitis due; occupational medicamentosa; like dermatitis; medicamentosa like ... See more keywords
A scoring system for the electrostatic complementarities of T‐cell receptors and cancer‐mutant amino acids: multi‐cancer analyses of associated survival rates
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13165
Abstract: The anti‐tumor immune response is considered to be due to the T‐cell receptor (TCR) binding to tumor antigens, which can be either wild‐type, early stem cell proteins, presumably foreign to a developed immune system; or… read more here.
Keywords: system; mutant amino; cancer; cdr3 ... See more keywords
Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-1632
Abstract: Purpose: Approximately 30% of patients with chronic lymphocytic leukemia (CLL) can be grouped into subsets with stereotyped B-cell receptor immunoglobulin (BcR IG) displaying remarkable similarity in the heavy complementarity-determining region 3 (VH CDR3). Here, we… read more here.
Keywords: leukemia; chronic lymphocytic; cdr3; cell ... See more keywords
Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities.
Sign Up to like & getrecommendations! Published in 2023 at "Cell systems"
DOI: 10.2139/ssrn.3971149
Abstract: Antigen-specific T cell receptor (TCR) sequences can have prognostic, predictive, and therapeutic value, but decoding the specificity of TCR recognition remains challenging. Unlike DNA strands that base pair, TCRs bind to their targets with different orientations… read more here.
Keywords: tcr; cdr3; entropic analysis; antigen specific ... See more keywords
Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050825
Abstract: Acute Respiratory Distress Syndrome (ARDS) is an illness that typically develops in people who are significantly ill or have serious injuries. ARDS is characterized by fluid build-up that occurs in the alveoli. T-cells are implicated… read more here.
Keywords: cdr3 sequences; acute respiratory; cdr3; respiratory distress ... See more keywords
Immune receptor CDR3 chemical features that preserve sequence information are highly efficient in reflecting survival distinctions: A pan-cancer analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical reports"
DOI: 10.3892/br.2022.1551
Abstract: Adaptive immune receptor (IR) chemical features have been used as signatures of an immune response for numerous medical conditions, raising the question of whether certain approaches to assessing the IR chemical features are more robust… read more here.
Keywords: chemical features; cdr3; sequence; immune receptor ... See more keywords