Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb
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DOI: 10.1080/19420862.2020.1763138
Abstract: ABSTRACT During the development of a therapeutic monoclonal antibody (mAb-1), the charge variant profile obtained by pH-gradient cation exchange chromatography (CEX) contained two main peaks, each of which exhibited a unique intrinsic fluorescence profile and… read more here.
Keywords: cdr3 loop; charge; variant profile; charge variant ... See more keywords