Pre‐ and post‐treatment blood‐based genomic landscape of patients with ROS1 or NTRK fusion‐positive solid tumours treated with entrectinib
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13214
Abstract: Genomic tumour profiling informs targeted treatment options. Entrectinib is a tyrosine kinase inhibitor with efficacy in NTRK fusion‐positive (‐fp) solid tumours and ROS1‐fp non‐small cell lung cancer. FoundationOne® Liquid CDx (F1L CDx), a non‐invasive in vitro… read more here.
Keywords: positive solid; fusion positive; ntrk fusion; treatment ... See more keywords
FoundationOne® CDx gene profiling in Japanese pancreatic ductal adenocarcinoma patients: a single-institution experience
Sign Up to like & getrecommendations! Published in 2020 at "Surgery Today"
DOI: 10.1007/s00595-020-02123-2
Abstract: Purpose The aim of this study was to investigate the genetic mutation profiles of Japanese pancreatic ductal adenocarcinoma (PDAC) patients. Methods Next-generation sequencing was performed using FoundationOne® CDx on 17 PDAC patients who were treated… read more here.
Keywords: japanese pancreatic; foundationone cdx; cdx; pancreatic ductal ... See more keywords
CDX-2 Expression in Esophageal Biopsies Without Goblet Cell Intestinal Metaplasia May Be Predictive of Barrett’s Esophagus
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05914-x
Abstract: Background CDX-2 is a nuclear homeobox transcription factor not normally expressed in esophageal and gastric epithelia, reported to highlight intestinal metaplasia (IM) in the esophagus. Pathological absence of goblet cells at initial screening via hematoxylin… read more here.
Keywords: intestinal metaplasia; barrett esophagus; goblet; cdx ... See more keywords
CDx, NGS and regulation: five perspectives from the Pistoia Alliance.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.07.002
Abstract: Companion diagnostics (CDx) are essential to the practice of precision medicine. Next-generation sequencing is an increasingly important tool in the development of CDx. However, for CDx to be deployed, many different biopharma industry sectors need… read more here.
Keywords: five perspectives; regulation five; ngs regulation; cdx ngs ... See more keywords
Impact of the new European Union In Vitro Diagnostics Regulation on the practice of hospital diagnostic laboratories
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2022.2087508
Abstract: ABSTRACT Objectives The In Vitro Diagnostics Regulation 2017/746 (IVDR) coming into force from May 2022, creates the first European regulatory recognition for biomarker tests linked to medicinal products, so-called companion diagnostics (CDx). Since the introduction… read more here.
Keywords: practice; diagnostics regulation; vitro diagnostics; hospital ... See more keywords
Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab657
Abstract: Abstract Transcriptional regulation by Wnt signalling is primarily thought to be accomplished by a complex of β-catenin and TCF family transcription factors (TFs). Although numerous studies have suggested that additional TFs play roles in regulating… read more here.
Keywords: tcf; cdx; wnt target; regulation ... See more keywords
Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-3453
Abstract: Purpose: ErbB3 and its ligand neuregulin-1 (NRG1) are widely expressed in head and neck squamous cell carcinoma (HNSCC) and associated with tumor progression. A “window-of-opportunity” study (NCT02473731) was conducted to evaluate the pharmacodynamic effects of… read more here.
Keywords: neck squamous; tumor; cdx; squamous cell ... See more keywords
Complete remission of Cdx-2 positive primary testicular carcinoid tumor: 10-years follow-up and literature review
Sign Up to like & getrecommendations! Published in 2020 at "BMC Urology"
DOI: 10.1186/s12894-020-00768-2
Abstract: Background The neuroendocrine cells can cause a variety of malignancies throughout the human body known as the neuroendocrine tumors (NETs) or carcinoid tumors. The primary testicular carcinoid tumor (PTCT) accounts for less than 1% of… read more here.
Keywords: carcinoid tumor; testicular carcinoid; cdx; primary testicular ... See more keywords
Mutation of amphioxus Pdx and Cdx demonstrates conserved roles for ParaHox genes in gut, anus and tail patterning
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00796-2
Abstract: The homeobox genes Pdx and Cdx are widespread across the animal kingdom and part of the small ParaHox gene cluster. Gene expression patterns suggest ancient roles for Pdx and Cdx in patterning the through-gut of… read more here.
Keywords: cdx; tail; amphioxus pdx; gene ... See more keywords
Wnt3a but not CDX-2 expression is associated with differentiated thyroid cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Associacao Medica Brasileira"
DOI: 10.1590/1806-9282.20211132
Abstract: OBJECTIVE Thyroid neoplasm incidence has increased worldwide, mostly due to the advancements in medical imaging and screening rates. The aberrant Wnt/β-catenin pathway has been identified as a key mechanism, and it has also been related… read more here.
Keywords: thyroid cancer; differentiated thyroid; expression; cdx ... See more keywords
Evaluation of Companion Diagnostics in Scientific Advice and Drug Marketing Authorization Applications by the European Medicines Agency
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.893028
Abstract: With the implementation of the new EU regulation on in vitro diagnostics (IVDR) in May 2022, notified bodies will be required to assess Companion Diagnostics (CDx). The EMA and national medicines agencies will be consulted… read more here.
Keywords: advice; marketing authorization; scientific advice; cdx ... See more keywords