Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12347
Abstract: We aimed to refine the value of CDX2 as an independent prognostic and predictive biomarker in colorectal cancer (CRC) according to disease stage and chemotherapy sensitivity in preclinical models. CDX2 expression was evaluated in 1045… read more here.
Keywords: chemotherapy; colorectal cancer; prognostic predictive; stage ... See more keywords
Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair‐deficient colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "BJS Open"
DOI: 10.1002/bjs5.91
Abstract: Caudal‐related homeobox transcription factor 2 (CDX2) is an intestine‐specific transcription factor implicated in tumour differentiation, proliferation, cell adhesion and migration. Negative CDX2 status (CDX2−) is associated with worse prognosis in colorectal cancer and may identify… read more here.
Keywords: prognosis; colorectal cancer; repair deficient; mismatch repair ... See more keywords
Prognostic significance of CDX2 immunoexpression in poorly differentiated clusters of colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2219-7
Abstract: CDX2 is a transcription factor that acts as a tumor suppressor in colorectal cancer (CRC). Its loss triggers metastatic process and tumor progression; however, its prognostic role in patients with CRC is still controversial. Poorly… read more here.
Keywords: cdx2 main; main tumor; cdx2 pdc; cdx2 ... See more keywords
The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2360-y
Abstract: Loss of CDX2 expression has been proposed to be a prognostic biomarker in colorectal cancer (CRC) correlating with shorter overall (OS) and progression-free survival (PFS). Since metastatic disease, mismatch repair (MMR) deficiency, and the mutational… read more here.
Keywords: status; cdx2 expression; status braf; mutational status ... See more keywords
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16840-2
Abstract: The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect… read more here.
Keywords: cdx2 expression; transformation; stem progenitor; hematopoietic stem ... See more keywords
CDX2 Expression in Primary and Metastatic Prostatic Adenocarcinoma: A Retrospective Study
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.128
Abstract: CDX2 encodes a transcription factor expressed in the nuclei of intestinal epithelial cells. The CDX2 immunohistochemical stain has excellent diagnostic utility in the setting of carcinoma of unknown primary, especially in combination with cytokeratins 7… read more here.
Keywords: positivity; study; primary metastatic; prostatic adenocarcinoma ... See more keywords
O-099 TEAD4 regulates trophectoderm differentiation upstream of CDX2 in human preimplantation embryos
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab125.069
Abstract: What is the main pathway regulating trophectoderm (TE) differentiation during pre-implantation development in mouse versus human embryos? TEAD4 is acting upstream of CDX2 and is involved in TE differentiation, as TEAD4-null human embryos exhibit compromised… read more here.
Keywords: embryos; crispr cas9; differentiation; development ... See more keywords
The broader phenotypic spectrum of congenital caudal abnormalities associated with mutations in the Caudal Type Homeobox 2 gene.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical genetics"
DOI: 10.1111/cge.14076
Abstract: The caudal type homeobox 2 (CDX2) gene encodes a developmental regulator involved in caudal body patterning. Only three pathogenic variants in human CDX2 have been described, in patients with persistent cloaca, sirenomelia and/or renal and… read more here.
Keywords: caudal type; type homeobox; caudal abnormalities; cdx2 ... See more keywords
CDX2 as a Predictive Biomarker Involved in Immunotherapy Response Suppresses Metastasis through EMT in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/9025668
Abstract: Background Studies have confirmed that Caudal Type Homeobox 2 (CDX2) plays a tumor suppressor role in colorectal cancer (CRC) and as a prognostic and predictive marker for colorectal cancer. The epithelial to mesenchymal transition (EMT)… read more here.
Keywords: involved immunotherapy; expression; cdx2; crc ... See more keywords
Abstract A033: Depletion of Apc gene in Cdx2 gastro-intestinal cells facilitates metastasis of colorectal adenocarcinoma Lgr5 cells to distant organs
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/1538-7445.crc22-a033
Abstract: Background: Caudal-type homeobox 2 (CDX2) is a transcription factor expressed in the gastro-intestinal (GI) epithelial (IEC) and stromal cells. CDX2 along with APC can regulate Lgr5 intestinal stem cell (ISC) differentiation to control GI development… read more here.
Keywords: lgr5; metastasis; depletion; lgr5 cells ... See more keywords
Abstract 532: Isolation of Human Placenta-derived Cdx2 Cells for Cardiac Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.532
Abstract: Coronary artery disease and heart failure are among the leading causes of mortality in United States and worldwide. The limited proliferation of the adult mammalian heart has prompted the need to recognize novel strategies that… read more here.
Keywords: term; cdx2 cells; cardiac regeneration; placenta ... See more keywords