CDX2 downregulation in mouse mural trophectoderm during peri‐implantation is heteronomous, dependent on the YAP‐TEAD pathway and controlled by estrogen‐induced factors
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DOI: 10.1002/rmb2.12446
Abstract: Abstract Purpose To investigate the transition of CDX2 expression patterns in mouse trophectoderm (TE) and its regulatory mechanisms during implantation. Methods Mouse E3.5–4.5 blastocysts were used to immunostain CDX2, YAP, TEAD4, and ESRRB. Endogenous estrogen… read more here.
Keywords: cdx2 downregulation; yap tead; cdx2 expression; estrogen ... See more keywords
The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2360-y
Abstract: Loss of CDX2 expression has been proposed to be a prognostic biomarker in colorectal cancer (CRC) correlating with shorter overall (OS) and progression-free survival (PFS). Since metastatic disease, mismatch repair (MMR) deficiency, and the mutational… read more here.
Keywords: status; cdx2 expression; status braf; mutational status ... See more keywords
Association of CDX2 Expression With Survival in Early Colorectal Cancer: A Systematic Review and Meta‐analysis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2018.02.001
Abstract: Abstract CDX2 is a homeobox gene encoding transcriptional factors for intestinal organogenesis and represents a specific marker of colorectal adenocarcinoma (CRC) differentiation. We have evaluated if CDX2 expression is associated with better overall and disease‐free… read more here.
Keywords: cdx2 expression; colorectal cancer; expression; meta analysis ... See more keywords
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
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DOI: 10.1038/s41467-020-16840-2
Abstract: The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect… read more here.
Keywords: cdx2 expression; transformation; stem progenitor; hematopoietic stem ... See more keywords
Diagnostic and Prognostic Roles of CDX2 Immunohistochemical Expression in Colorectal Cancers
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DOI: 10.3390/diagnostics12030757
Abstract: The study is aimed to evaluate the diagnostic and prognostic role of the immunohistochemical expression of the Caudal-type homeobox transcription factor 2 (CDX2) in colorectal cancers (CRCs) through a meta-analysis. By searching relevant databases, 38… read more here.
Keywords: colorectal cancers; immunohistochemical expression; expression; diagnostic prognostic ... See more keywords