Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100734
Abstract: Vasculogenic mimicry (VM) promotes tumor migration, metastasis, and invasion in various types of cancer, but the relationship between VM and these phenotypes remains undefined. In this study, we examined carcinoembryonic antigen cell adhesion molecule 1… read more here.
Keywords: ceacam1; vasculogenic mimicry; cell adhesion; carcinoembryonic antigen ... See more keywords
CEACAM1 structure and function in immunity and its therapeutic implications.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in immunology"
DOI: 10.1016/j.smim.2019.101296
Abstract: The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and… read more here.
Keywords: ceacam1; function immunity; immunity therapeutic; ceacam1 structure ... See more keywords
Mice lacking PECAM-1 and Ceacam1 have an aberrant platelet and thrombus phenotype.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1663-8108
Abstract: The immunoglobulin (Ig)-immunoreceptor tyrosine-based inhibitory motif (ITIM) bearing receptors, PECAM-1 and CEACAM1 have been shown net negative regulators of platelet-collagen interactions and hemi-ITAM signalling pathways. In this study, a double knockout (DKO) mouse was developed… read more here.
Keywords: dko platelets; ceacam1; pecam ceacam1; platelet ... See more keywords
Investigation of the Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 in Diabetic Retinopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2023.2192272
Abstract: PURPOSE Diabetic retinopathy (DR) has become a major cause of blindness with increased prevalence of diabetic mellitus. Carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) plays a part in pathological neovascularization. This study aimed to investigate the… read more here.
Keywords: antigen related; role; ceacam1; diabetic retinopathy ... See more keywords
Vascular inflammaging: Endothelial CEACAM1 expression is upregulated by TNF‐α via independent activation of NF‐κB and β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2024 at "Aging Cell"
DOI: 10.1111/acel.14384
Abstract: Chronic inflammation with progressive age, called inflammaging, contributes to the pathogenesis of cardiovascular diseases. Previously, we have shown increased vascular expression of the Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) in aged mice and humans,… read more here.
Keywords: endothelial ceacam1; vascular inflammaging; ceacam1; catenin ... See more keywords
Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12700
Abstract: CEACAM1 and CEACAM6 belong to the carcinoembryonic antigen (CEA) family and may play an immune‐modulatory role during pregnancy. The aim of the study was to determine the blood serum levels of soluble CEACAM1 and CEACAM6… read more here.
Keywords: ceacam1; soluble ceacam1; pregnancy; blood serum ... See more keywords
The tRNA-derived fragment 5'tRF-Gly promotes the development of hepatocellular carcinoma via direct targeting of CEACAM1.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15505
Abstract: tRNA-derived fragments are a group of small non-coding single-stranded RNA that play essential roles in multiple diseases. However, their biological functions in carcinogenesis are not well understood. In this study, 5'tRF-Gly was found to have… read more here.
Keywords: hepatocellular carcinoma; trf; ceacam1; trna derived ... See more keywords
Mechanism and function of CEACAM1 splice isoforms
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.14350
Abstract: Alternative splicing is a fundamental mechanism in the post‐transcriptional regulation of genes. The multifunctional transmembrane glycoprotein receptor carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) undergoes extensive alternative splicing to allow for tunable functions in cell… read more here.
Keywords: ceacam1; function ceacam1; mechanism function; splice isoforms ... See more keywords
Serum Level of CEACAM1 in Patients with Nonsmall Cell Lung Cancer and Its Clinical Significance in Cancer Tissue
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/7948010
Abstract: Objective To analyze the expression of CEACAM1 in serum of patients with nonsmall cell lung cancer (NSCLC) and to explore the correlation and clinical significance between the expression of CEACAM1 and pathological parameters of NSCLC… read more here.
Keywords: lung cancer; ceacam1; cancer tissue; cancer ... See more keywords
Abstract B117: Phase 1 study of CM24 in combination with nivolumab in patients with advanced pancreatic cancer - Survival, potential biomarker and effect on neutrophil extracellular traps (NETs)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.panca2023-b117
Abstract: Background: The monoclonal antibody CM24 blocks the activity of carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), which is known to have several important roles in cancer progression, immune evasion, and metastasis. The homophilic interaction of… read more here.
Keywords: ceacam1; cancer; phase study; pdac patients ... See more keywords
Characterizing the Tumor Suppressor Role of CEACAM1 in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000487730
Abstract: Background/Aims: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin (Ig) superfamily that belongs to the carcinoembryonic antigen (CEA) family which plays a dual role in cancer.… read more here.
Keywords: ceacam1; ceacam1 multiple; multiple myeloma; expression ... See more keywords