Companion gene mutations and their clinical significance in AML with double mutant CEBPA
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-019-0133-7
Abstract: Acute myeloid leukemia (AML) with double mutant CEBPA (CEBPAdm) is generally associated with favorable prognosis, but the heterogeneity still blatant and needs further exploration. We aimed to comprehensively analyze the companion genetic abnormalities and their… read more here.
Keywords: aml double; gene mutations; cebpa; cebpadm ... See more keywords
CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2016158
Abstract: ABSTRACT NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated… read more here.
Keywords: cell; cebpa; aml cells; aml cell ... See more keywords
METTL3/14 and IL-17 signaling contribute to CEBPA-DT enhanced oral cancer cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.14083
Abstract: OBJECTIVES Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Chemotherapy has been recognized as an optional combination treatment, which enhance the overall survival of OSCC patients. However, the majority of… read more here.
Keywords: chemoresistance; oscc chemoresistance; cebpa; resistance ... See more keywords
Abstract LB192: MTL-CEBPA in combination with pembrolizumab converts an immune desert to an inflamed TME in solid tumors resistant to checkpoint blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb192
Abstract: Despite significant advances in outcomes with immunotherapy, most cancer patients do not benefit from currently approved immune checkpoint inhibitors (ICI). The reasons for ICI resistance are multi-faceted and suggest that additional immunomodulation is required to… read more here.
Keywords: cebpa; inflamed tme; mtl cebpa; combination ... See more keywords
Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML
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DOI: 10.1182/blood-2019-124773
Abstract: Acute Myeloid Leukemia (AML) results from the stepwise accumulation of mutations from distinct functional classes, ultimately culminating in malignant transformation. Based on their oncogenic activity, mutations can be classified into three distinct groups. Class I… read more here.
Keywords: cebpa; membership entity; csf3r; differentiation ... See more keywords
CEBPA bZip Mutations are Associated with Favorable Prognosis in de novo AML: A Report from the Children's Oncology Group.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009652
Abstract: Bi-allelic CEBPA mutations are associated with favorable outcomes in AML. We evaluated the clinical and biologic implications of CEBPA-bZip mutations in childhood/young adult newly diagnosed AML. CEBPA-bZip mutation status was determined in 2,958 AML patients… read more here.
Keywords: cebpa bzip; associated favorable; cebpa; mutations associated ... See more keywords
C/EBPα induces Ebf1 gene expression in common lymphoid progenitors
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DOI: 10.1371/journal.pone.0244161
Abstract: C/EBPα is required for formation of granulocyte-monocyte progenitors (GMP) and also participates in B lymphopoiesis. The common lymphoid progenitor (CLP) and preproB populations but not proB cells express Cebpa, and pan-hematopoietic deletion of the +37… read more here.
Keywords: clp; cebpa; deletion; common lymphoid ... See more keywords
Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.806137
Abstract: Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of new evidence makes it necessary to reconsider the subsets and… read more here.
Keywords: myeloid leukemia; progress; cebpa; acute myeloid ... See more keywords