Companion gene mutations and their clinical significance in AML with double mutant CEBPA
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-019-0133-7
Abstract: Acute myeloid leukemia (AML) with double mutant CEBPA (CEBPAdm) is generally associated with favorable prognosis, but the heterogeneity still blatant and needs further exploration. We aimed to comprehensively analyze the companion genetic abnormalities and their… read more here.
Keywords: aml double; gene mutations; cebpa; cebpadm ... See more keywords
CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2016158
Abstract: ABSTRACT NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated… read more here.
Keywords: cell; cebpa; aml cells; aml cell ... See more keywords
Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish
Sign Up to like & getrecommendations! Published in 2024 at "Open Biology"
DOI: 10.1098/rsob.240215
Abstract: The CCAAT enhancer binding protein alpha (CEBPA) is crucial for myeloid differentiation and the balance of haematopoietic stem and progenitor cell (HSPC) quiescence and self-renewal, and its dysfunction can drive leukemogenesis. However, its role in… read more here.
Keywords: haematopoietic stem; generation; cebpa; hspc ... See more keywords
METTL3/14 and IL-17 signaling contribute to CEBPA-DT enhanced oral cancer cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.14083
Abstract: OBJECTIVES Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Chemotherapy has been recognized as an optional combination treatment, which enhance the overall survival of OSCC patients. However, the majority of… read more here.
Keywords: chemoresistance; oscc chemoresistance; cebpa; resistance ... See more keywords
Abstract LB192: MTL-CEBPA in combination with pembrolizumab converts an immune desert to an inflamed TME in solid tumors resistant to checkpoint blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb192
Abstract: Despite significant advances in outcomes with immunotherapy, most cancer patients do not benefit from currently approved immune checkpoint inhibitors (ICI). The reasons for ICI resistance are multi-faceted and suggest that additional immunomodulation is required to… read more here.
Keywords: cebpa; inflamed tme; mtl cebpa; combination ... See more keywords
Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124773
Abstract: Acute Myeloid Leukemia (AML) results from the stepwise accumulation of mutations from distinct functional classes, ultimately culminating in malignant transformation. Based on their oncogenic activity, mutations can be classified into three distinct groups. Class I… read more here.
Keywords: cebpa; membership entity; csf3r; differentiation ... See more keywords
FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance
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DOI: 10.1182/blood-2024-205887
Abstract: Introduction. FLT3-ITD AMLs resist standard chemotherapy at high rates by unknown mechanisms. Chemotherapy aims to upregulate p53 (TP53) the master regulator of apoptosis (‘cytotoxicity‘). In normal myelopoiesis, p53 is suppressed by continuous proteolysis, presumably to… read more here.
Keywords: flt3 itd; flt3; cebpa; p53 ... See more keywords
CEBPA Regulates Molecular Kinetics of RNA Polymerase I in Myeloid Progenitors
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-211714
Abstract: Ribosomal RNA (rRNA) is the most abundant cellular RNA, and its transcription from 300-600 copies of rDNA repeats by RNA polymerase I (Pol I) is the most energy intensive transcriptional process in the cell. Different… read more here.
Keywords: rdna; cebpa; pol; cell ... See more keywords
The myeloid transcription factor cebpa functions as a sequence-specific RNA binding protein via a novel n-terminal domain essential for macrophage differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-188
Abstract: Introduction: CCAAT/Enhancer Binding Protein Alpha (CEBPa) is a master regulator indispensable for neutrophil development, yet its precise role in macrophage maturation has remained elusive. This functionality has been historically attributed exclusively to its DNA-binding bZIP… read more here.
Keywords: cebpa; rna; macrophage; rna binding ... See more keywords
CEBPA bZip Mutations are Associated with Favorable Prognosis in de novo AML: A Report from the Children's Oncology Group.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009652
Abstract: Bi-allelic CEBPA mutations are associated with favorable outcomes in AML. We evaluated the clinical and biologic implications of CEBPA-bZip mutations in childhood/young adult newly diagnosed AML. CEBPA-bZip mutation status was determined in 2,958 AML patients… read more here.
Keywords: cebpa bzip; associated favorable; cebpa; mutations associated ... See more keywords
Integrative analysis of aging-related genes reveals CEBPA as a novel therapeutic target in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Cell International"
DOI: 10.1186/s12935-024-03457-4
Abstract: To explore the impact of ARGs on the prognosis of NSCLC, and its correlation with clinicopathological parameters and immune microenvironment. Preliminary research on the biological functions of CEBPA in NSCLC. Using consensus clustering analysis to… read more here.
Keywords: cebpa; analysis; risk; cell ... See more keywords