CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
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DOI: 10.1182/blood.2025028954
Abstract: Acute myeloid leukemias (AMLs) have an overall poor prognosis with many high-risk cases co-opting stem-cell gene regulatory programs, yet the mechanisms through which this occurs remain poorly understood. Increased expression of the stem-cell transcription factor,… read more here.
Keywords: leukemias; stem cell; repression mecom; cebpa repression ... See more keywords