Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105768
Abstract: Cat eye syndrome chromosome region candidate 2 (CECR2) bromodomain is a module of CECR2-containing remodeling factor (CERF), which is a chromatin remodeling complex correlating with transcriptional control and adjustment of chromatin architecture. Potent chemical probes… read more here.
Keywords: pyrimidine scaffold; cecr2 brd; pyrrolo pyrimidine; cecr2 bromodomain ... See more keywords
Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells
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DOI: 10.1038/s41598-020-73500-7
Abstract: Bromodomain (BRD), a protein module that recognizes acetylated lysine residues on histones and other proteins, has recently emerged as a promising therapeutic target for human diseases such as cancer. While most of the studies have… read more here.
Keywords: nvs cecr2; cytotoxic activity; cecr2; cancer cells ... See more keywords
Cecr2 mutant mice as a model for human cat eye syndrome
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DOI: 10.1038/s41598-021-82556-y
Abstract: Cat eye syndrome (CES), a human genetic disorder caused by the inverted duplication of a region on chromosome 22, has been known since the late 1890s. Despite the significant impact this disorder has on affected… read more here.
Keywords: model; eye syndrome; cecr2; cat eye ... See more keywords
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
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DOI: 10.1126/scitranslmed.abf5473
Abstract: Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. To… read more here.
Keywords: cancer; breast cancer; metastasis; cancer metastasis ... See more keywords