The Safety and Economic Impact of Cefazolin versus Nafcillin for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections
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DOI: 10.1007/s40121-017-0148-z
Abstract: IntroductionAnti-staphylococcal penicillins are generally accepted as first-line therapy for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, but their use may be limited by interstitial nephritis and acute kidney injury. Alternatives include first-generation cephalosporins including cefazolin.MethodsWe conducted a… read more here.
Keywords: methicillin susceptible; staphylococcus aureus; susceptible staphylococcus; cefazolin ... See more keywords
Computational design of penicillin acylase variants with improved kinetic selectivity for the enzymatic synthesis of cefazolin
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DOI: 10.1016/j.bej.2021.108149
Abstract: Abstract Enzymatic synthesis plays a pivotal role in the sustainable production of semi-synthetic β-lactam antibiotics. However, these types of green syntheses are being developed slowly because of a lack of appropriate enzymes. In the present… read more here.
Keywords: enzymatic synthesis; synthesis; kinetic selectivity; penicillin acylase ... See more keywords
Photocatalytic degradation of Cefazolin over spherical nanoparticles of TiO2/ZSM-5 mesoporous nanoheterojunction under simulated solar light
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DOI: 10.1016/j.eti.2020.101070
Abstract: Abstract A nanoheterojunction photocatalyst of the spherical titanium dioxide (TSN) over ZSM-5 mesoporous was synthesized by the ecofriendly direct co-template technique with assisting of the solvent evaporation to photodegrade harmful Cefazolin compound from drinking water… read more here.
Keywords: compound; cefazolin; zsm mesoporous; nanoheterojunction photocatalyst ... See more keywords
Cefazolin vs. anti-staphylococcal penicillins for treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections in acutely ill adult patients: Results of a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.11.013
Abstract: A systematic literature review and meta-analysis was conducted to evaluate the comparative efficacy and tolerability of cefazolin vs. anti-staphylococcal penicillins (ASPs) for methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). Utilizing published regression models, included studies… read more here.
Keywords: review meta; analysis; treatment; cefazolin anti ... See more keywords
Nafcillin versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2018.02.004
Abstract: BACKGROUND Anti-staphylococcal penicillins have long been the first-line treatment option for methicillin-susceptible Staphylococcus aureus (MSSA) infections. Recent retrospective data comparing nafcillin and cefazolin report similar clinical efficacy despite concerns about high inoculum MSSA infections. METHODS… read more here.
Keywords: methicillin susceptible; staphylococcus aureus; susceptible staphylococcus; treatment ... See more keywords
Association between Pre-Operative Cefazolin Dose and Surgical Site Infection in Obese Patients.
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DOI: 10.1089/sur.2016.182
Abstract: BACKGROUND A fixed dose of cefazolin results in serum concentrations that decrease as body mass increases. Current national guidelines suggest a pre-operative cefazolin dose of two grams may be insufficient for patients ≥120 kg; thus a… read more here.
Keywords: pre operative; three gram; site; operative cefazolin ... See more keywords
Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw496
Abstract: Objectives: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. Patients and methods: This study included… read more here.
Keywords: surgery; cardiopulmonary bypass; dosing regimens; cardiac surgery ... See more keywords
Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass
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DOI: 10.1093/jac/dkx439
Abstract: Objectives Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether adequate concentrations are achieved in this patient population. The goal of our study was… read more here.
Keywords: surgery; cefazolin antimicrobial; cardiac surgery; closure concentrations ... See more keywords
Impact of Choice of Prophylaxis on the Microbiology of Cardiac Implantable Electronic Device Infections: Insights from the Prevention of Arrhythmia Device infection Trial (PADIT)
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DOI: 10.1093/ofid/ofab513
Abstract: The Prevention of Arrhythmia Device Infection Trial (PADIT) investigated whether intensification of perioperative prophylaxis could prevent cardiac implantable electronic device (CIED) infections. Compared with a single dose of cefazolin, the peri-operative administration of cefazolin, vancomycin,… read more here.
Keywords: infection; prevention arrhythmia; prophylaxis; microbiology ... See more keywords
Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients
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DOI: 10.1093/ofid/ofab649
Abstract: Abstract Background The relative distribution of cefazolin into the cerebrospinal fluid (CSF) remains debated. Determining the distribution of cefazolin into the CSF in noninfected adults may allow for further treatment applications of cefazolin. This prospective… read more here.
Keywords: cerebrospinal fluid; cefazolin cerebrospinal; cefazolin; critically ill ... See more keywords
Modeling Likelihood of Coverage for Narrow Spectrum Antibiotics in Patients Hospitalized with Urinary Tract Infections
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DOI: 10.1093/ofid/ofx163.632
Abstract: Abstract Background When prescribing empiric antibiotics, providers try to choose the narrowest spectrum antibiotic that will cover a patient’s infection. To do this they must assess the likelihood of coverage of different regimens. We developed… read more here.
Keywords: urinary tract; likelihood coverage; spectrum antibiotics; spectrum ... See more keywords