Effect of Cefepime on Neurotoxicity Development in Critically Ill Adults with Renal Dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Chest"
DOI: 10.1016/j.chest.2020.01.051
Abstract: BACKGROUND Pharmacodynamic and pathophysiologic changes in critically ill adults receiving cefepime may increase the risk of adverse events. This study evaluated the impact of cefepime exposure on neurotoxicity development in critically ill adults with renal… read more here.
Keywords: cefepime; renal dysfunction; ill adults; critically ill ... See more keywords
Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.105863
Abstract: Cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer antibiotic under development, was designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Currently, aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V)… read more here.
Keywords: cefepime; vitro activity; cza atm; wck 5222 ... See more keywords
Simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin in human serum using an isotope‐dilution HPLC–MS/MS method
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.01.031
Abstract: &NA; The aim of the current study was to develop and validate a robust multi‐analyte high performance liquid chromatography tandem mass spectrometry (HPLC–MS/MS) method for simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin,… read more here.
Keywords: quantification; cefepime; moxifloxacin; meropenem ciprofloxacin ... See more keywords
Low-Level Cefepime Exposure Induces High-Level Resistance in Environmental Bacteria: Molecular Mechanism and Evolutionary Dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c00793
Abstract: Antibiotics exert selective pressures on clinically relevant antibiotic resistance. It is critical to understand how antibiotic resistance evolves in environmental microbes exposed to subinhibitory concentrations of antibiotics and whether evolutionary dynamics and emergence of resistance… read more here.
Keywords: evolutionary dynamics; antibiotic resistance; resistance evolution; cefepime ... See more keywords
Cefepime-induced encephalopathy: socio-clinical patterns and electroencephalographic findings
Sign Up to like & getrecommendations! Published in 2025 at "Arquivos de Neuro-Psiquiatria"
DOI: 10.1055/s-0045-1812469
Abstract: Abstract Background Cefepime is an antibiotic widely used for severe infections in hospital . However, its use can lead to encephalopathy, which is detected by electroencephalogram (EEG). Objective To establish the socioclinical pattern of cefepime… read more here.
Keywords: clinical patterns; cefepime induced; cefepime; socio clinical ... See more keywords
Statistical design and optimization of nano-transfersomes based chitosan gel for transdermal delivery of cefepime
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2024.2353098
Abstract: Abstract Objectives This research aimed to overcome challenges posed by cefepime excessive elimination rate and poor patient compliance by developing transdermal delivery system using nano-transfersomes based chitosan gel. Methods Rotary evaporation-sonication method and the Box-Behnken… read more here.
Keywords: based chitosan; cpe ntfs; cefepime; transdermal delivery ... See more keywords
Novel beta-lactamase inhibitors with cefepime: where do they fit in clinical practice?
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2025.2558990
Abstract: ABSTRACT Introduction Enmetazobactam, taniborbactam, and zidebactam are novel β-lactamase inhibitors that have been combined with cefepime in an effort to overcome common and emerging mechanisms of antimicrobial resistance. Areas covered We performed a literature review… read more here.
Keywords: clinical practice; cefepime; lactamase inhibitors; taniborbactam ... See more keywords
In vivo pharmacokinetic/pharmacodynamic evaluation of cefepime/taniborbactam combination against cefepime-non-susceptible Enterobacterales and Pseudomonas aeruginosa in a murine pneumonia model
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac446
Abstract: Abstract Background Cefepime/taniborbactam is a cephalosporin/bicyclic boronate β-lactamase inhibitor combination in clinical development for nosocomial pneumonia due to MDR Gram-negative bacteria. A murine pneumonia model was used to characterize cefepime/taniborbactam in vivo pharmacodynamics against Enterobacterales… read more here.
Keywords: combination; pneumonia model; cefepime; cefepime taniborbactam ... See more keywords
Incidence of Nephrotoxicity Among Pediatric Patients Receiving Vancomycin With Either Piperacillin-Tazobactam or Cefepime: A Cohort Study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piy030
Abstract: Background Recent studies in adults have found an incidence of acute kidney injury (AKI) in patients treated with a combination of vancomycin and piperacillin-tazobactam (TZP) that is greater than that expected with either medication alone.… read more here.
Keywords: incidence; vancomycin; cefepime; combination ... See more keywords
The Impact of Concomitant Empiric Cefepime on Patient Outcomes of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections Treated With Vancomycin
Sign Up to like & getrecommendations! Published in 2019 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofz079
Abstract: Abstract Background Data suggest that vancomycin + β-lactam combinations improve clearance of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs). However, it is unclear which specific β-lactams confer benefit. This analysis evaluates the impact of concomitant… read more here.
Keywords: vancomycin; cefepime; methicillin resistant; concomitant empiric ... See more keywords
725. WCK 5222 (Cefepime/Zidebactam): An In Vitro Assessment of Activity Compared with Current Dual-Antibiotic Options Against Multidrug-Resistant Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2019 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofz360.793
Abstract: Abstract Background Pseudomonas aeruginosa (PSA) is an opportunistic pathogen known to cause complications in critically ill patients worldwide. In those at risk of infection with multidrug-resistant strains (MDR-PSA), dual antibiotic therapy is often considered. However,… read more here.
Keywords: cefepime; susceptibility; wck 5222; wck ... See more keywords