In vivo pharmacokinetic/pharmacodynamic evaluation of cefepime/taniborbactam combination against cefepime-non-susceptible Enterobacterales and Pseudomonas aeruginosa in a murine pneumonia model
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DOI: 10.1093/jac/dkac446
Abstract: Abstract Background Cefepime/taniborbactam is a cephalosporin/bicyclic boronate β-lactamase inhibitor combination in clinical development for nosocomial pneumonia due to MDR Gram-negative bacteria. A murine pneumonia model was used to characterize cefepime/taniborbactam in vivo pharmacodynamics against Enterobacterales… read more here.
Keywords: combination; pneumonia model; cefepime; cefepime taniborbactam ... See more keywords
Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales
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DOI: 10.1128/aac.00842-25
Abstract: ABSTRACT We evaluated the activity of aztreonam-avibactam and comparators tested against 490 MBL-producing Enterobacterales isolates collected in 27 countries during 2019–2022. The most common MBL was NDM-1, which was detected among 307 isolates. The genes… read more here.
Keywords: mbl producing; aztreonam avibactam; activity aztreonam; cefepime taniborbactam ... See more keywords
In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program
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DOI: 10.1128/aac.01281-22
Abstract: Taniborbactam is a novel cyclic boronate β-lactamase inhibitor in clinical development in combination with cefepime. We assessed the in vitro activity of cefepime-taniborbactam and comparators against a 2018–2020 collection of Enterobacterales (n = 13,731) and Pseudomonas aeruginosa… read more here.
Keywords: activity cefepime; vitro activity; taniborbactam; cefepime taniborbactam ... See more keywords
Impact of porin deletions on cefepime-taniborbactam activity against Klebsiella pneumoniae
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DOI: 10.1128/aac.01672-24
Abstract: ABSTRACT We determined the frequency of resistance to cefepime-taniborbactam in NDM-1-producing Klebsiella pneumoniae at read more here.
Keywords: impact porin; cefepime taniborbactam; porin deletions; klebsiella pneumoniae ... See more keywords
In Vitro Activity of Cefepime-Taniborbactam against Carbapenemase-Producing Enterobacterales and Pseudomonas aeruginosa Isolates Recovered in Spain
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DOI: 10.1128/aac.02161-21
Abstract: Novel β-lactam–β-lactamase inhibitor combinations currently approved for clinical use are poorly active against metallo-β-lactamase (MBL)-producing strains. We evaluated the in vitro activity of cefepime-taniborbactam (FTB [formerly cefepime–VNRX-5133]) and comparator agents against carbapenemase-producing Enterobacterales (n = 247) and… read more here.
Keywords: vitro activity; cefepime taniborbactam; producing enterobacterales; activity cefepime ... See more keywords
Klebsiella pneumoniae Mutants Resistant to Ceftazidime-Avibactam Plus Aztreonam, Imipenem-Relebactam, Meropenem-Vaborbactam, and Cefepime-Taniborbactam
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02179-21
Abstract: We show that a previously described Klebsiella pneumoniae variant that is resistant to ceftazidime-avibactam plus meropenem-vaborbactam, has a ramR plus ompK36 mutation, and produces the V239G variant KPC-3 (V240G per the standard numbering system) exhibits… read more here.
Keywords: cefepime taniborbactam; avibactam plus; ceftazidime avibactam;
Establishing the reference broth microdilution MIC method for cefepime-taniborbactam
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00661-25
Abstract: ABSTRACT The investigational β-lactam/β-lactamase inhibitor combination cefepime-taniborbactam is intended as therapy for serious infections caused by Gram-negative pathogens resistant to third-generation cephalosporins and carbapenems. Establishing a susceptibility testing reference method for cefepime-taniborbactam that conforms to… read more here.
Keywords: method; microbiology; reference; cefepime ... See more keywords
Cefepime-taniborbactam demonstrates potent in vitro activity vs Enterobacterales with blaOXA-48
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DOI: 10.1128/spectrum.01144-24
Abstract: ABSTRACT Taniborbactam (formerly VNRX-5133) is a novel, investigational boronic acid β-lactamase inhibitor. The combination of cefepime (FEP) with taniborbactam is active against Enterobacterales carrying class A, B, C, and/or D enzymes. We assessed the activity… read more here.
Keywords: taniborbactam; clinical strains; fep taniborbactam; cefepime ... See more keywords
In Vitro Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Enterobacterales Collected in India
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DOI: 10.1128/spectrum.04925-22
Abstract: The study revealed the differential ability of cefepime/taniborbactam and cefepime/zidebactam in tackling carbapenemase-producing Indian clinical isolates that also harbored additional mechanisms of resistance. NDM-expressing E. coli with 4-amino-acid insert in PBP3 are predominately resistant to… read more here.
Keywords: cefepime taniborbactam; cefepime; activity; carbapenemase ... See more keywords