Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
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DOI: 10.1007/s40121-020-00385-4
Abstract: Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods… read more here.
Keywords: body infections; gram negative; foreign body; negative pathogens ... See more keywords
Treatment of carbapenem-resistant Pseudomonas aeruginosa infections: a case for cefiderocol
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DOI: 10.1080/14787210.2022.2071701
Abstract: ABSTRACT Introduction Carbapenem-resistant (CR) Pseudomonas aeruginosa infections constitute a serious clinical threat globally. Patients are often critically ill and/or immunocompromised. Antibiotic options are limited and are currently centered on beta-lactam–beta-lactamase inhibitor (BL–BLI) combinations and the… read more here.
Keywords: treatment; aeruginosa infections; carbapenem resistant; cefiderocol ... See more keywords
Activity of Cefiderocol Against Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Endemic to Medical Centers in New York City
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DOI: 10.1089/mdr.2019.0298
Abstract: Therapeutic options for the treatment of infections owing to multidrug-resistant Gram-negative pathogens are often limited. Cefiderocol is a novel siderophore cephalosporin with activity against Gram-negative pathogens, including many multidrug-resistant strains. The activity of cefiderocol was… read more here.
Keywords: pseudomonas aeruginosa; enterobacterales pseudomonas; activity cefiderocol; cefiderocol ... See more keywords
Does Cefiderocol Have a Potential Role in Cystic Fibrosis Pulmonary Exacerbation Management?
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DOI: 10.1089/mdr.2020.0602
Abstract: Cystic fibrosis (CF) is associated with frequent pulmonary exacerbations and the need for novel antibiotics against antimicrobial resistance. Cefiderocol is a newly approved therapeutic option active against a variety of multidrug resistant (MDR) bacteria such… read more here.
Keywords: potential role; cystic fibrosis; cefiderocol potential; cefiderocol ... See more keywords
In Vitro Activity of Cefiderocol Against Meropenem-Nonsusceptible Gram-Negative Bacilli with Defined β-Lactamase Carriage: SIDERO-WT Surveillance Studies, 2014-2019.
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DOI: 10.1089/mdr.2022.0279
Abstract: We examined the in vitro susceptibility of meropenem-nonsusceptible Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii complex isolates from five consecutive annual SIDERO-WT surveillance studies (2014-2019) to cefiderocol and comparator agents in the context of their carbapenemase… read more here.
Keywords: meropenem; complex isolates; cefiderocol; meropenem nonsusceptible ... See more keywords
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
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DOI: 10.1093/jac/dkaa117
Abstract: Abstract Background Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli (MDR-GNB). Objectives To assess the in vitro antibacterial activity of cefiderocol against a collection of MDR-GNB clinical isolates from hospitals… read more here.
Keywords: pseudomonas aeruginosa; activity cefiderocol; baumannii pseudomonas; cefiderocol ... See more keywords
Cefiderocol: EUCAST criteria for disc diffusion and broth microdilution for antimicrobial susceptibility testing
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DOI: 10.1093/jac/dkac080
Abstract: Abstract Objectives The reproducibility of cefiderocol MIC determination using broth microdilution (BMD) in iron-depleted CAMHB (ID-CAMHB) was investigated, and the EUCAST disc diffusion (DD) method for cefiderocol susceptibility testing was developed and validated against reference… read more here.
Keywords: broth microdilution; cefiderocol; susceptibility testing; disc diffusion ... See more keywords
Comment on: Bacteraemia with an MBL-producing Klebsiella pneumoniae: treatment and the potential role of cefiderocol heteroresistance
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DOI: 10.1093/jac/dkac277
Abstract: © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https:// creativecommons.org/licenses/by-nc/4.0/),… read more here.
Keywords: dilution; broth microdilution; pneumoniae; cefiderocol ... See more keywords
In vivo efficacy & resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam or meropenem using human-simulated regimens versus Acinetobacter baumannii
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DOI: 10.1093/jac/dkad032
Abstract: Abstract Objective Evaluate the in vivo efficacy and resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam and meropenem using human-simulated regimens (HSR) in the murine infection model. Methods In total, 15 clinical A. baumannii… read more here.
Keywords: resistance; ampicillin sulbactam; cefiderocol; ceftazidime avibactam ... See more keywords
Stability and low induction propensity of cefiderocol against chromosomal AmpC β-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae
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DOI: 10.1093/jac/dky482
Abstract: Objectives: The siderophore cephalosporin cefiderocol possesses in vitro activity against MDR Gram-negative bacteria. The stability of cefiderocol against serine- and metallo-type carbapenemases has been reported previously, but little is known about how cefiderocol interacts with… read more here.
Keywords: chromosomal ampc; induction; ampc lactamases; cefiderocol ... See more keywords
Intrapulmonary pharmacokinetics of cefiderocol, a novel siderophore cephalosporin, in healthy adult subjects
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DOI: 10.1093/jac/dkz123
Abstract: Abstract Background Cefiderocol, a novel siderophore cephalosporin, has shown potent activity against Gram-negative bacteria, including MDR pathogens. Cefiderocol is under clinical investigation for the treatment of serious Gram-negative infections including nosocomial pneumonia. Objectives This study… read more here.
Keywords: healthy adult; novel siderophore; siderophore cephalosporin; cefiderocol novel ... See more keywords