Penicillin-binding protein 1b encoded by mrcB gene mediates the enhancement of biofilm formation by sub-inhibitory concentrations of cefotaxime in monophasic Salmonella Typhimurium strain SH16SP46.
Sign Up to like & getrecommendations! Published in 2023 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnad021
Abstract: Development of cefotaxime-resistance and biofilm formation increase the difficulty to prevent and control the infection and contamination of Salmonella, one of the most important foodborne and zoonotic bacterial pathogen. Our previous study observed that 1/8… read more here.
Keywords: biofilm formation; salmonella; strain; formation ... See more keywords
Extended-spectrum β-lactamase-producing Escherichia coli contributes to the survival of cefotaxime-susceptible E. coli under high concentrations of cefotaxime by acquisition of increased AmpC expression.
Sign Up to like & getrecommendations! Published in 2018 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fny009
Abstract: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-E) are becoming increasingly widespread in Vietnam. Antibiotics are detected in many Vietnamese foods; however, the effect of ESBL-E and antibiotic consumption on intestinal bacteria has not been studied sufficiently. Here,… read more here.
Keywords: cefotaxime; extended spectrum; coli; producing escherichia ... See more keywords
Optimal dosing of cefotaxime and desacetylcefotaxime for critically ill paediatric patients. Can we use microsampling?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac168
Abstract: Objectives: This study aimed to describe the population pharmacokinetics of cefotaxime and desacetylcefotaxime in critically ill paediatric patients and provide dosing recommendations. We also sought to evaluate the use of capillary microsampling to facilitate data-rich… read more here.
Keywords: paediatric patients; critically ill; ill paediatric; desacetylcefotaxime critically ... See more keywords
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02244-18
Abstract: Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers… read more here.
Keywords: ceftriaxone; volunteers treated; ceftriaxone cefotaxime; intestinal microbiota ... See more keywords
Subinhibitory Cefotaxime and Levofloxacin Concentrations Contribute to Selection of Pseudomonas aeruginosa in Coculture with Staphylococcus aureus
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DOI: 10.1128/aem.00592-22
Abstract: Increasing evidence has demonstrated the polymicrobial characteristics of most chronic infections, and the frequent communications among bacterial pathogens result in many difficulties for clinical therapy. Exploring bacterial interspecific interaction during antibiotic treatment is an emerging… read more here.
Keywords: interaction; aeruginosa coculture; subinhibitory; aureus ... See more keywords
Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella
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DOI: 10.1128/spectrum.02145-21
Abstract: Understanding mechanisms of antibiotic resistance is crucial to guide how best to use antibiotics to minimize emergence of resistance. We used a laboratory evolution system to study how Salmonella responds to cefotaxime in both planktonic… read more here.
Keywords: mutations within; antibiotic resistance; salmonella; biofilm ... See more keywords
Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.916253
Abstract: Objective: The perspective of real-world study is especially relevant to newborns, enabling dosage regimen optimization and regulatory approval of medications for use in newborns. The aim of the present study was to conduct a pharmacokinetic… read more here.
Keywords: early onset; model; developmental pharmacokinetic; cefotaxime ... See more keywords
Evaluation of synergism between Cefotaxime and Allium sativum against Extended-spectrum beta-lactamase and Ambler class C co-producers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Pharmaceutical Science"
DOI: 10.7324/japs.2019.90314
Abstract: The present study evaluates the synergistic association between Cefotaxime and aqueous garlic (Allium sativum) extract (AGE) on Extended spectrum beta-lactamase (ESBL) and Ambler Class C (AmpC) co-producing E.coli strains from Skin and soft tissue infections… read more here.
Keywords: cefotaxime; age; beta lactamase; cefotaxime age ... See more keywords