258. A Comparison of Cefprozil and Fluoroquinolones for Gram-Negative Bacteremia
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DOI: 10.1093/ofid/ofaa439.302
Abstract: Beta lactams and fluoroquinolones (FQ) have been evaluated as step-down therapy options for Gram-negative bacteremia (GNB), but the preferred oral step-down antibiotic remains unclear. This retrospective, non-inferiority, cohort study included adult patients who received oral… read more here.
Keywords: gram negative; negative bacteremia; treatment; step ... See more keywords
Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma
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DOI: 10.1155/2018/6959761
Abstract: Background Both cis- and trans-cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. Methods An… read more here.
Keywords: development validation; validation hplc; method; method rapid ... See more keywords
Population Pharmacokinetics of Cis-, Trans-, and Total Cefprozil in Healthy Male Koreans
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DOI: 10.3390/pharmaceutics11100531
Abstract: Cefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (PPKs). A PPK model for cefprozil… read more here.
Keywords: healthy male; male koreans; model; total cefprozil ... See more keywords