Successful ceftazidime–avibactam therapy in a patient with multidrug-resistant Pseudomonas aeruginosa infective endocarditis
Sign Up to like & getrecommendations! Published in 2022 at "Infection"
DOI: 10.1007/s15010-022-01834-7
Abstract: Pseudomonas aeruginosa is an opportunistic Gram-negative bacillus that causes serious infections. This pathogen has several intrinsic resistance mechanisms that can result in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains [1]. As a result, infections due… read more here.
Keywords: multidrug resistant; endocarditis; ceftazidime; aeruginosa infective ... See more keywords
Activity of aztreonam in combination with ceftazidime-avibactam against serine- and metallo-β-lactamase-producing Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2020.115227
Abstract: Existing data support the combination of aztreonam and ceftazidime-avibactam against serine-β-lactamase (SBL)- and metallo-β-lactamase (MBL)-producing Enterobacterales, although there is a paucity of data against SBL- and MBL-producing Pseudomonas aeruginosa. In this study, 5 SBL- and… read more here.
Keywords: ceftazidime avibactam; combination; avibactam serine; aztreonam ceftazidime ... See more keywords
Electrochemical oxidation of ceftazidime with graphite/CNT-Ce/PbO2-Ce anode: Parameter optimization, toxicity analysis and degradation pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114436
Abstract: In this work, the electrochemical degradation of antibiotic ceftazidime has been studied using a novel rare earth metal Ce and carbon nanotubes codoped PbO2 electrode. A competitively high oxygen evolution potential (2.4 V) and enhanced catalytic… read more here.
Keywords: degradation; pbo2 electrode; ceftazidime; pbo2 ... See more keywords
Successful treatment of KPC-MDR septic shock with ceftazidime-avibactam in a pediatric critically ill patient
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DOI: 10.1016/j.idcr.2019.e00634
Abstract: Ceftazidime–avibactam is a combination agent consisting of the β-lactamase inhibitor avibactam and the broad-spectrum cephalosporin ceftazidime. There are no published case reports or studies evaluating the use of CAZ-AVI in pediatric critically ill patients. We… read more here.
Keywords: ceftazidime avibactam; pediatric critically; successful treatment; critically ill ... See more keywords
In vitro antibacterial activity of ceftazidime/avibactam in combination against planktonic and biofilm carbapenemase-producing Klebsiella pneumoniae isolated from blood
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.07.028
Abstract: Abstract Objectives The aim of this study was to report on in vitro tests of antibacterial activity of ceftazidime/avibactam in combination against planktonic or biofilm KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp), the rate of KPC-Kp blood… read more here.
Keywords: combination; activity; biofilm; ceftazidime ... See more keywords
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
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DOI: 10.1021/acs.biochem.7b00176
Abstract: CTX-M β-lactamases provide resistance against the β-lactam antibiotic, cefotaxime, but not a related antibiotic, ceftazidime. β-Lactamases that carry the P167S substitution, however, provide ceftazidime resistance. In this study, CTX-M-14 was used as a model to… read more here.
Keywords: p167s; conformational change; ctx lactamases; ceftazidime ... See more keywords
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0353
Abstract: Burkholderia cepacia complex (Bcc) in airways of patients with cystic fibrosis (CF) is associated with an increased morbidity and mortality. A huge range of intrinsic antimicrobial resistances challenges the treatment of Bcc infections. The aim… read more here.
Keywords: bcc; ceftazidime; ceftazidime avibactam; susceptibility ... See more keywords
Optimization of therapy against Pseudomonas aeruginosa with ceftazidime and meropenem using chemostats as model for infections
Sign Up to like & getrecommendations! Published in 2017 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnx142
Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in patients admitted to intensive care units. Resistance rapidly develops against two drugs of choice: ceftazidime and meropenem. Several therapeutic protocols were compared for… read more here.
Keywords: therapy; pseudomonas aeruginosa; resistance; ceftazidime ... See more keywords
In vitro activity of ceftazidime/avibactam and comparators against Gram-negative bacterial isolates collected from Latin American centres between 2015 and 2017
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaa089
Abstract: Abstract Objectives We report the in vitro activity of ceftazidime/avibactam and comparators against 7729 Enterobacterales isolates and 2053 Pseudomonas aeruginosa isolates collected from six Latin American countries between 2015 and 2017. Methods A central reference… read more here.
Keywords: ceftazidime avibactam; susceptibility; vitro activity; ceftazidime ... See more keywords
In vivo translational assessment of the GES genotype on the killing profile of ceftazidime, ceftazidime/avibactam and meropenem against Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac232
Abstract: Abstract Objectives To evaluate the in vivo killing profile of human-simulated exposures of ceftazidime, ceftazidime/avibactam and meropenem against GES-harbouring Pseudomonas aeruginosa in the murine thigh infection model. Methods Five P. aeruginosa isolates [three isogenic (GES-1,… read more here.
Keywords: ceftazidime; ceftazidime ceftazidime; avibactam meropenem; ceftazidime avibactam ... See more keywords
Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw587
Abstract: Objectives When tested in broth, avibactam reverses ceftazidime resistance in many Pseudomonas aeruginosa that express ESBLs. We examined whether similar reversal is observed against intracellular forms of P. aeruginosa . Methods Strains: reference strains; two… read more here.
Keywords: pseudomonas aeruginosa; intracellular forms; extracellular intracellular; ceftazidime ... See more keywords