Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime-Avibactam in Pediatric Patients Aged 3 Months and Older.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2460
Abstract: Increasing prevalence of infections caused by antimicrobial-resistant Gram-negative bacteria represents a global health crisis, and while several novel therapies that target various aspects of antimicrobial resistance have been introduced in recent years, few are currently… read more here.
Keywords: ceftazidime avibactam; months older; population pharmacokinetic; avibactam pediatric ... See more keywords
Successful ceftazidime–avibactam therapy in a patient with multidrug-resistant Pseudomonas aeruginosa infective endocarditis
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DOI: 10.1007/s15010-022-01834-7
Abstract: Pseudomonas aeruginosa is an opportunistic Gram-negative bacillus that causes serious infections. This pathogen has several intrinsic resistance mechanisms that can result in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains [1]. As a result, infections due… read more here.
Keywords: multidrug resistant; endocarditis; ceftazidime; aeruginosa infective ... See more keywords
Ceftazidime-Avibactam: A Review in the Treatment of Serious Gram-Negative Bacterial Infections
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DOI: 10.1007/s40265-018-0902-x
Abstract: Ceftazidime-avibactam (Zavicefta®) is an intravenously administered combination of the third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase inhibitor avibactam. In the EU, ceftazidime-avibactam is approved for the treatment of adults with complicated urinary tract infections… read more here.
Keywords: ceftazidime avibactam; gram negative; treatment; avibactam review ... See more keywords
Activity of aztreonam in combination with ceftazidime-avibactam against serine- and metallo-β-lactamase-producing Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2020.115227
Abstract: Existing data support the combination of aztreonam and ceftazidime-avibactam against serine-β-lactamase (SBL)- and metallo-β-lactamase (MBL)-producing Enterobacterales, although there is a paucity of data against SBL- and MBL-producing Pseudomonas aeruginosa. In this study, 5 SBL- and… read more here.
Keywords: ceftazidime avibactam; combination; avibactam serine; aztreonam ceftazidime ... See more keywords
Successful treatment of KPC-MDR septic shock with ceftazidime-avibactam in a pediatric critically ill patient
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DOI: 10.1016/j.idcr.2019.e00634
Abstract: Ceftazidime–avibactam is a combination agent consisting of the β-lactamase inhibitor avibactam and the broad-spectrum cephalosporin ceftazidime. There are no published case reports or studies evaluating the use of CAZ-AVI in pediatric critically ill patients. We… read more here.
Keywords: ceftazidime avibactam; pediatric critically; successful treatment; critically ill ... See more keywords
Carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection successfully treated with ceftazidime/avibactam plus tigecycline
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DOI: 10.1016/j.idcr.2020.e00745
Abstract: Ceftazidime/avibactam combines ceftazidime with a new beta-lactam that successfully that inhibits Amber Class A and D carbapenemases. We report a clinical case of a 61 year-old man with a carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection after… read more here.
Keywords: ceftazidime avibactam; carbapenemase producing; pneumoniae intra; producing klebsiella ... See more keywords
Native mitral valve endocarditis associated with KPC producing Serratia marcescens bacteremia successfully treated with mitral valve replacement and ceftazidime-avibactam
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DOI: 10.1016/j.idcr.2021.e01137
Abstract: Highlights • First case of native valve endocarditis due to Klebsiella Pneumomiae carbapenemase (KPC) producing Serratia marcescens.• Patient underwent mitral valve replacement and was treated with monotherapy ceftazidime-avibactam during 6 weeks.• Long term treatment with… read more here.
Keywords: ceftazidime avibactam; valve endocarditis; producing serratia; mitral valve ... See more keywords
Loss of activity of ceftazidime-avibactam due to MexAB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis.
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DOI: 10.1016/j.ijantimicag.2018.07.027
Abstract: In Pseudomonas aeruginosa (P. aeruginosa) collected from cystic fibrosis (CF) patients, 24% resistance to ceftazidime-avibactam in isolates negative for carbapenemases and extended-spectrum β-lactamases (ESBLs) has previously been observed. The current study aimed to unravel the… read more here.
Keywords: ceftazidime avibactam; mexab oprm; avibactam;
Comparison of methods to analyse susceptibility of German MDR/XDR Pseudomonas aeruginosa to ceftazidime/avibactam.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.05.001
Abstract: Ceftazidime/avibactam (CZA) is a new β-lactam/β-lactamase inhibitor combination with promising properties as avibactam can inhibit a broad range of β-lactamases (e.g. blaKPC, blaOXA-48). The objectives of this study were: (i) to assess CZA susceptibility rates;… read more here.
Keywords: ceftazidime avibactam; xdr pseudomonas; pseudomonas aeruginosa; cza ... See more keywords
In vitro antibacterial activity of ceftazidime/avibactam in combination against planktonic and biofilm carbapenemase-producing Klebsiella pneumoniae isolated from blood
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DOI: 10.1016/j.jgar.2020.07.028
Abstract: Abstract Objectives The aim of this study was to report on in vitro tests of antibacterial activity of ceftazidime/avibactam in combination against planktonic or biofilm KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp), the rate of KPC-Kp blood… read more here.
Keywords: combination; activity; biofilm; ceftazidime ... See more keywords
MIC Profiling of Ceftazidime-Avibactam against two Carbapenemase producing Klebsiella pneumoniae Isolates.
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DOI: 10.1016/j.jgar.2020.10.014
Abstract: OBJECTIVE To correlate results of a modified susceptibility testing method to outcomes of ceftazidime-avibactam (CAZ/AVI) therapy. METHODS Two bloodstreamK. pneumoniae isolates (CAZ/AVI susceptible) from an abdominal source were recovered from 2 unrelated patients. Both patients… read more here.
Keywords: ceftazidime avibactam; caz avi; mic profiling; caz ... See more keywords