A novel STK1-targeted small-molecule as an “antibiotic resistance breaker” against multidrug-resistant Staphylococcus aureus
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DOI: 10.1038/s41598-017-05314-z
Abstract: Ser/Thr protein kinase (STK1) plays a critical role in cell wall biosynthesis of and drug resistance in methicillin-resistant Staphylococcus aureus (MRSA). MRSA strains lacking STK1 become susceptible to failing cephalosporins, such as Ceftriaxone and Cefotaxime.… read more here.
Keywords: staphylococcus aureus; ceftriaxone cefotaxime; resistant staphylococcus; resistance ... See more keywords
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens
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DOI: 10.1128/aac.02244-18
Abstract: Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers… read more here.
Keywords: ceftriaxone; volunteers treated; ceftriaxone cefotaxime; intestinal microbiota ... See more keywords