Lovo‐cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB‐206 study
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26741
Abstract: lovo‐cel (bb1111; LentiGlobin for sickle cell disease [SCD]) gene therapy (GT) comprises autologous transplantation of hematopoietic stem and progenitor cells transduced with the BB305 lentiviral vector encoding a modified β‐globin gene (βA‐T87Q) to produce anti‐sickling… read more here.
Keywords: lovo cel; cel; treatment process;
Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying
Sign Up to like & getrecommendations! Published in 2018 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.01.007
Abstract: Hypromellose acetate succinate (HPMCAS) microparticles containing the poorly-water soluble drug celecoxib (CEL) were prepared by electrospraying intended for oral drug delivery. Various solvent mixtures with different solubility for CEL and HPMCAS were used to induce… read more here.
Keywords: drug; solvent mixtures; hpmcas; prepared electrospraying ... See more keywords
A novel formation pathway of Nε-(carboxyethyl)lysine from lactic acid during high temperature exposure in wheat sourdough bread and chemical model.
Sign Up to like & getrecommendations! Published in 2022 at "Food chemistry"
DOI: 10.1016/j.foodchem.2022.132942
Abstract: Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) have been the most extensively studied advanced glycation end-products (AGEs) in foods. Their formation mechanism, especially the latter, has not been clearly delineated in fermented food. In this work, the… read more here.
Keywords: carboxyethyl lysine; formation; bread; sourdough bread ... See more keywords
Physicochemical and biopharmaceutical characterization of celecoxib nanoparticle: Avoidance of delayed oral absorption caused by impaired gastric motility
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.051
Abstract: ABSTRACT The present study aimed to develop a celecoxib (CEL) nanoparticle with improved dissolution/dispersion and consistent absorption even in the presence of impaired gastric motility. CEL was pulverized by a wet‐milling with hydroxypropyl cellulose (HPC),… read more here.
Keywords: absorption; dissolution dispersion; nanoparticle; gastric motility ... See more keywords
Analytical determination of CML and CEL in oral use tobacco products by HPLC-MS/MS method
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106338
Abstract: Abstract Exogenous dietary advanced glycation endproducts (AGEs) have been suggested to increase health risk. Oral use tobacco products are used as substitute for cigarette smoking due to their “reduced risk” and no second-hand smoke. They… read more here.
Keywords: cml cel; cel; use; oral use ... See more keywords
Earthquake induced sloshing and hydrodynamic pressures in rigid liquid storage tanks analyzed by coupled acoustic-structural and Euler-Lagrange methods
Sign Up to like & getrecommendations! Published in 2019 at "Thin-Walled Structures"
DOI: 10.1016/j.tws.2018.10.016
Abstract: Abstract Three-dimensional (3-D) ground-supported cylindrical and rectangular rigid liquid storage tanks filled with water and subjected to seismic base excitation are investigated using finite element method (FEM). The analyses of the tanks are carried out… read more here.
Keywords: cas; approach; liquid storage; rigid liquid ... See more keywords
Functionalization of Porous Cellulose with Glyoxyl Groups as a Carrier for Enzyme Immobilization and Stabilization.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01608
Abstract: The functionalization of the internal surface of macroporous carriers with glyoxyl groups has proven to highly stabilize a large variety of enzymes through multipoint covalent immobilization. In this work, we have translated the surface chemistry… read more here.
Keywords: immobilization; glyoxyl groups; carrier; glyoxyl ... See more keywords
Multifunctional Nanoplatform for Mild Microwave-Enhanced Thermal, Antioxidative, and Chemotherapeutic Treatment of Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19198
Abstract: Rheumatoid arthritis (RA) is usually associated with excessive proliferation of M1-type proinflammatory macrophages, resulting in severe hypoxia and excess reactive oxygen species (ROS) in the joint cavity. Inhibiting M1-type proinflammatory macrophages and/or repolarizing them into… read more here.
Keywords: uio nh2; microwave enhanced; rheumatoid arthritis; treatment ... See more keywords
Safety and feasibility of outpatient chimeric antigen receptor (CAR) T-cell therapy: experience from a tertiary care center
Sign Up to like & getrecommendations! Published in 2022 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-022-01664-z
Abstract: TO THE EDITOR: Chimeric antigen receptor (CAR) T-cell therapies are adoptive cell immunotherapies that have led to remarkable patient outcomes and transformed the treatment landscape in relapsed or refractory (R/R) B-cell malignancies and multiple myeloma… read more here.
Keywords: therapy; tisa cel; cell; car cell ... See more keywords
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2032482
Abstract: Abstract Rheumatoid arthritis (RA) is an ordinarily occurring autoimmune disease with systemic inflammatory. Targeted drug delivery systems have many successful applications in the treatment of rheumatoid arthritis. In order to develop nanoparticles for targeted delivery… read more here.
Keywords: rheumatoid arthritis; arthritis; dextran sulfate; treatment ... See more keywords
Phenotypic Composition of Commercial Anti-CD19 CAR T Cells Affects In Vivo Expansion and Disease Response in Patients with Large B-cell Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-0164
Abstract: Abstract Purpose: In clinical trials, the expansion and persistence of chimeric antigen receptor (CAR) T cells correlate with therapeutic efficacy. However, properties of CAR T cells that enable their in vivo proliferation have still to… read more here.
Keywords: cell; response; car; expansion ... See more keywords