Lovo‐cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB‐206 study
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26741
Abstract: lovo‐cel (bb1111; LentiGlobin for sickle cell disease [SCD]) gene therapy (GT) comprises autologous transplantation of hematopoietic stem and progenitor cells transduced with the BB305 lentiviral vector encoding a modified β‐globin gene (βA‐T87Q) to produce anti‐sickling… read more here.
Keywords: lovo cel; cel; treatment process;
Aberrant localization of β1 integrin in podocyte cytoplasm of primary FSGS with cellular lesion
Sign Up to like & getrecommendations! Published in 2024 at "Virchows Archiv"
DOI: 10.1007/s00428-024-03919-0
Abstract: Podocyte detachment is a major trigger in pathogenesis of focal segmental glomerulosclerosis (FSGS). Detachment via β1 integrin (ITGB1) endocytosis, associated with endothelial cell injury, has been reported in animal models but remains unknown in human… read more here.
Keywords: cel cel; cel; mcns; podocyte ... See more keywords
Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying
Sign Up to like & getrecommendations! Published in 2018 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.01.007
Abstract: Hypromellose acetate succinate (HPMCAS) microparticles containing the poorly-water soluble drug celecoxib (CEL) were prepared by electrospraying intended for oral drug delivery. Various solvent mixtures with different solubility for CEL and HPMCAS were used to induce… read more here.
Keywords: drug; solvent mixtures; hpmcas; prepared electrospraying ... See more keywords
A novel formation pathway of Nε-(carboxyethyl)lysine from lactic acid during high temperature exposure in wheat sourdough bread and chemical model.
Sign Up to like & getrecommendations! Published in 2022 at "Food chemistry"
DOI: 10.1016/j.foodchem.2022.132942
Abstract: Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) have been the most extensively studied advanced glycation end-products (AGEs) in foods. Their formation mechanism, especially the latter, has not been clearly delineated in fermented food. In this work, the… read more here.
Keywords: carboxyethyl lysine; formation; bread; sourdough bread ... See more keywords
Physicochemical and biopharmaceutical characterization of celecoxib nanoparticle: Avoidance of delayed oral absorption caused by impaired gastric motility
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.051
Abstract: ABSTRACT The present study aimed to develop a celecoxib (CEL) nanoparticle with improved dissolution/dispersion and consistent absorption even in the presence of impaired gastric motility. CEL was pulverized by a wet‐milling with hydroxypropyl cellulose (HPC),… read more here.
Keywords: absorption; dissolution dispersion; nanoparticle; gastric motility ... See more keywords
Analytical determination of CML and CEL in oral use tobacco products by HPLC-MS/MS method
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106338
Abstract: Abstract Exogenous dietary advanced glycation endproducts (AGEs) have been suggested to increase health risk. Oral use tobacco products are used as substitute for cigarette smoking due to their “reduced risk” and no second-hand smoke. They… read more here.
Keywords: cml cel; cel; use; oral use ... See more keywords
Earthquake induced sloshing and hydrodynamic pressures in rigid liquid storage tanks analyzed by coupled acoustic-structural and Euler-Lagrange methods
Sign Up to like & getrecommendations! Published in 2019 at "Thin-Walled Structures"
DOI: 10.1016/j.tws.2018.10.016
Abstract: Abstract Three-dimensional (3-D) ground-supported cylindrical and rectangular rigid liquid storage tanks filled with water and subjected to seismic base excitation are investigated using finite element method (FEM). The analyses of the tanks are carried out… read more here.
Keywords: cas; approach; liquid storage; rigid liquid ... See more keywords
Functionalization of Porous Cellulose with Glyoxyl Groups as a Carrier for Enzyme Immobilization and Stabilization.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01608
Abstract: The functionalization of the internal surface of macroporous carriers with glyoxyl groups has proven to highly stabilize a large variety of enzymes through multipoint covalent immobilization. In this work, we have translated the surface chemistry… read more here.
Keywords: immobilization; glyoxyl groups; carrier; glyoxyl ... See more keywords
Multifunctional Nanoplatform for Mild Microwave-Enhanced Thermal, Antioxidative, and Chemotherapeutic Treatment of Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19198
Abstract: Rheumatoid arthritis (RA) is usually associated with excessive proliferation of M1-type proinflammatory macrophages, resulting in severe hypoxia and excess reactive oxygen species (ROS) in the joint cavity. Inhibiting M1-type proinflammatory macrophages and/or repolarizing them into… read more here.
Keywords: uio nh2; microwave enhanced; rheumatoid arthritis; treatment ... See more keywords
Cysteamine/Amberlyst-15-Mediated Cellulose Dissolution for Engineering Antioxidative Nanodrug in Diabetic Wound Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c18122
Abstract: Cellulose-based materials offer sustainable potential but require greener processes for advanced applications. Here, we developed a deep eutectic solvent-liked system for dissolving cellulose, composed of molten cysteamine hydrochloride (CysHCl) combined with solid acid Amberlyst-15 (A15).… read more here.
Keywords: cel; cys cel; cel gel; diabetic wound ... See more keywords
Screening, Synthesis, and Characterization of a More Rapidly Dissolving Celecoxib Crystal Form
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c03188
Abstract: The prevalence of poor solubility in active pharmaceutical ingredients (APIs) such as celecoxib (CEL) is a major bottleneck in the pharmaceutical industry, leading to a low concentration gradient, poor passive diffusion, and in vivo failure.… read more here.
Keywords: celecoxib; cel; screening synthesis; synthesis characterization ... See more keywords