Celastrol acts as a new histone deacetylase inhibitor to inhibit colorectal cancer cell growth via regulating macrophage polarity
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11952
Abstract: The tumorigenesis and progression of colorectal cancer are closely related to the tumor microenvironment, especially inflammatory response. Inhibitors of histone deacetylase (HDAC) have been reported as epigenetic regulators of the immune system to treat cancer… read more here.
Keywords: inhibitor; colorectal cancer; cancer cell; celastrol ... See more keywords
Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21982
Abstract: The global emergence of coronavirus disease 2019 (COVID‐19) has caused substantial human casualties. Clinical manifestations of this disease vary from asymptomatic to lethal, and the symptomatic form can be associated with cytokine storm and hyperinflammation.… read more here.
Keywords: human cysteine; cov replication; celastrol; viral human ... See more keywords
Celastrol reverses palmitic acid (PA)‐caused TLR4‐MD2 activation‐dependent insulin resistance via disrupting MD2‐related cellular binding to PA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26547
Abstract: Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation‐dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA)… read more here.
Keywords: md2; insulin; celastrol; md2 activation ... See more keywords
Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down‐regulating microRNA‐21
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6359
Abstract: Celastrol could inhibit cancer cell growth in vitro. However, effect(s) of celastrol on gastric cancer is not well studied. Therefore, we investigated the effects of celastrol on human gastric cancer cell line MKN45 and the… read more here.
Keywords: gastric cancer; celastrol; cancer cell; human gastric ... See more keywords
Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.09.010
Abstract: background and purpose: Celastrol, a quinone methide triterpene isolated from the root extracts of Tripterygium wilfordii, can greatly induce the gene expression activity of heme oxygenase‐1 (HO‐1) to achieve disease prevention and control. HO‐1 induction… read more here.
Keywords: celastrol; anti hcv; expression; replication ... See more keywords
Celastrol ameliorates acute liver injury through modulation of PPARα.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114058
Abstract: Celastrol, derived from the roots of the Tripterygium Wilfordi, has attracted interest for its potential anti-inflammatory and lipid-lowering activities. In the present study, the protective effect of celastrol on carbon tetrachloride (CCl4)-induced acute liver injury… read more here.
Keywords: ppar; celastrol ameliorates; acute liver; celastrol ... See more keywords
Enhanced production of celastrol in Tripterygium wilfordii hairy root cultures by overexpression of TwSQS2
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107681
Abstract: Abstract Celastrol with various bioactivities is a triterpenoid compound derived from Tripterygium wilfordii which is an important medicinal plant. The limited resources restrict the industrialization of celastrol. To enhance the content of celastrol, a new… read more here.
Keywords: celastrol; twsqs2; tripterygium wilfordii; hairy ... See more keywords
Celastrol in cancer therapy: Recent developments, challenges and prospects.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.08.030
Abstract: Cancer is one of the world's biggest healthcare burdens and despite the current advancements made in treatment plans, the outcomes for oncology patients have yet to reach their full potential. Hence, there is a pressing… read more here.
Keywords: therapy recent; celastrol; cancer; cancer therapy ... See more keywords
Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.09.031
Abstract: Background Celastrol is an active ingredient of Chinese medicine Tripterygium wilfordii which is clinically used to treat the immune diseases. Currently, celastrol is documented as a potent agent for treating cancer and inflammatory disorders. This… read more here.
Keywords: cisplatin nephrotoxicity; mitochondrial function; cisplatin; celastrol ... See more keywords
Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.058
Abstract: Celastrol and its derivatives have been reported for their potent anticancer activity. Among other celastrol analogues, novel carbamate derivatives were designed and synthesised, and their biological activity on the viability of human cancer cell lines… read more here.
Keywords: design synthesis; celastrol derivatives; celastrol; cancer ... See more keywords
Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.013
Abstract: To develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were… read more here.
Keywords: inhibition; celastrol derivatives; releasing celastrol; celastrol ... See more keywords