Celastrol ameliorates acute liver injury through modulation of PPARα.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114058
Abstract: Celastrol, derived from the roots of the Tripterygium Wilfordi, has attracted interest for its potential anti-inflammatory and lipid-lowering activities. In the present study, the protective effect of celastrol on carbon tetrachloride (CCl4)-induced acute liver injury… read more here.
Keywords: ppar; celastrol ameliorates; acute liver; celastrol ... See more keywords
Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18619
Abstract: Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3… read more here.
Keywords: inflammasome activation; celastrol ameliorates; celastrol; inflammatory diseases ... See more keywords
Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.963506
Abstract: Objectives: Osteoarthritis (OA) is a joint disease characterized by degeneration of joint cartilage and is a significant cause of severe joint pain, physical disability, and impaired quality of life in the aging population. Celastrol, a… read more here.
Keywords: celastrol ameliorates; signaling pathway; tlr2 signaling; celastrol ... See more keywords