Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds.
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DOI: 10.1016/j.ejmech.2017.08.058
Abstract: Celastrol and its derivatives have been reported for their potent anticancer activity. Among other celastrol analogues, novel carbamate derivatives were designed and synthesised, and their biological activity on the viability of human cancer cell lines… read more here.
Keywords: design synthesis; celastrol derivatives; celastrol; cancer ... See more keywords
Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities.
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DOI: 10.1016/j.ejmech.2018.10.013
Abstract: To develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were… read more here.
Keywords: inhibition; celastrol derivatives; releasing celastrol; celastrol ... See more keywords
Synthesis and characterisation of celastrol derivatives as potential anticancer agents
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DOI: 10.1080/14756366.2017.1404590
Abstract: Abstract In the present study, three series of novel celastrol derivatives were designed and synthesised by modifying the carboxylic acid at the 20th position with amino acid, amine, and triazole derivatives. All the synthesised compounds… read more here.
Keywords: synthesis characterisation; cell lines; characterisation celastrol; celastrol derivatives ... See more keywords