Real-World Hepatic Safety of Oral Acetaminophen versus Loxoprofen/Celecoxib: Using a Nationwide Electronic Medical Record Database.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2216
Abstract: The aim of this study was to investigate the incidence of liver injury associated with acetaminophen compared with commonly prescribed two non-steroidal anti-inflammatory drugs, loxoprofen and celecoxib, over one-year period. This study used an electronic… read more here.
Keywords: celecoxib; liver injury; loxoprofen celecoxib; electronic medical ... See more keywords
Efficacy of celecoxib as preemptive analgesia for patients undergoing laparoscopic inguinal hernia repair: a randomized trial
Sign Up to like & getrecommendations! Published in 2021 at "Surgery Today"
DOI: 10.1007/s00595-020-02199-w
Abstract: To investigate the efficacy and safety of preemptive analgesia with a transversus abdominis plane (TAP) block versus celecoxib for patients undergoing laparoscopic transabdominal preperitoneal inguinal hernia repair (LTAPP). Sixty patients scheduled for LTAPP were randomized… read more here.
Keywords: block; celecoxib; group; patients undergoing ... See more keywords
Celecoxib-Dependent Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion (tMCAO) Involves Modifications in Unfolded Protein Response (UPR) and Proteasome.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02202-y
Abstract: Stroke is one of the main causes of death and disability worldwide. Ischemic stroke results in unfolded/misfolded protein accumulation in endoplasmic reticulum (ER), a condition known as ER stress. We hypothesized that previously reported neuroprotection… read more here.
Keywords: protein; cerebral artery; celecoxib; middle cerebral ... See more keywords
Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0861-2
Abstract: Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis. The predominant hepatic metabolism of celecoxib to celecoxib carboxylic acid (CCA) is mediated mainly by CYP2C9. We investigated the… read more here.
Keywords: pharmacokinetics celecoxib; celecoxib; cyp2c9 genetic; carboxylic acid ... See more keywords
Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103029
Abstract: Three novel series of diarylpyrazole 10b-d and triarylpyrazole derivatives 11a-d &12a-d were synthesized through Vilsmier-Haack condition. The structures of prepared compounds were determined through IR, 1H NMR, 13C NMR, Mass spectral and elemental analysis. Docking… read more here.
Keywords: design synthesis; celecoxib; celecoxib tolmetin; tolmetin drug ... See more keywords
Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108863
Abstract: Gentamicin-induced nephrotoxicity has been well documented, although the causing mechanisms and preventative measures need further investigation. The current study aimed to explore the potential protective impacts of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on gentamicin-induced… read more here.
Keywords: protein; celecoxib; gentamicin; induced nephrotoxicity ... See more keywords
BOXIT-A Randomised Phase III Placebo-controlled Trial Evaluating the Addition of Celecoxib to Standard Treatment of Transitional Cell Carcinoma of the Bladder (CRUK/07/004).
Sign Up to like & getrecommendations! Published in 2019 at "European urology"
DOI: 10.1016/j.eururo.2018.09.020
Abstract: BACKGROUND Non-muscle-invasive bladder cancer (NMIBC) has a significant risk of recurrence despite adjuvant intravesical therapy. OBJECTIVE To determine whether celecoxib, a cyclo-oxygenase 2 inhibitor, reduces the risk of recurrence in NMIBC patients receiving standard treatment.… read more here.
Keywords: risk; celecoxib; recurrence; high risk ... See more keywords
Evaluation of cardiovascular risk associated with SKI306X use in patients with osteoarthritis and rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.06.003
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE SKI306X (Joins®) is an anti-inflammatory analgesic herbal medicine extract that was clinically approved for treatment of osteoarthritis in the previous trials and shown to be effective on follow-up studies. However, its potential cardiovascular… read more here.
Keywords: medicine; risk; celecoxib; osteoarthritis rheumatoid ... See more keywords
The Effect of Celecoxib in Traumatic Heterotopic Ossification around Temporomandibular Joint in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.01.014
Abstract: OBJECTIVE In this study, the role of inflammation in traumatic heterotopic ossification around temporomandibular joint (THO-TMJ), as well as the preventive and treatment effect of celecoxib in THO-TMJ both in vivo and in vitro were… read more here.
Keywords: heterotopic ossification; celecoxib; tho tmj; traumatic heterotopic ... See more keywords
[Is celecoxib a safe alternative for the Fernand Widal syndrome?]
Sign Up to like & getrecommendations! Published in 2018 at "Revue des maladies respiratoires"
DOI: 10.1016/j.rmr.2017.09.007
Abstract: The Fernand Widal syndrome is a set of associations between asthma, nasal polyposis and aspirin sensitivity. Selective cyclo-oxygenase 2 (COX 2) inhibitors are recognized as being a therapeutic alternative in cases needing analgesic or anti-inflammatory treatment.… read more here.
Keywords: patients fernand; fernand widal; widal syndrome; celecoxib ... See more keywords
Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c03556
Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) generate heat upon exposure to an alternating magnetic field (AMF), which has been studied for hyperthermia treatment and triggered drug release. This study introduces a novel application of magnetic hyperthermia… read more here.
Keywords: celecoxib; amorphization; dosage forms; oral dosage ... See more keywords