CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3′ UTR Elements
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108531
Abstract: SUMMARY CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we… read more here.
Keywords: analysis celf6; massively parallel; parallel functional; clip massively ... See more keywords
Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning
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DOI: 10.1111/gbb.12593
Abstract: In addition to gene expression differences in distinct cell types, there is substantial post‐transcriptional regulation driven in part by RNA binding proteins (RBPs). Loss‐of‐function RBP mutations have been associated with neurodevelopmental disorders, such as Fragile‐X… read more here.
Keywords: response; conditioning; rna binding; celf6 ... See more keywords
RNA-binding protein CELF6 modulates transcription and splicing levels of genes associated with tumorigenesis in lung cancer A549 cells
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DOI: 10.7717/peerj.13800
Abstract: CELF6 (CUGBP Elav-Like Family Member 6), a canonical RNA binding protein (RBP), plays important roles in post-transcriptional regulation of pre-mRNAs. However, the underlying mechanism of lower expressed CELF6 in lung cancer tissues is still unclear.… read more here.
Keywords: lung cancer; rna binding; celf6; binding protein ... See more keywords