FRI0513 Long-term (156 weeks) improvements in physical function of dmard-naÏve and dmard/biologic-experienced psoriatic arthritis patients treated with apremilast: data from a large database of 4 phase iii clinical trials
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DOI: 10.1136/annrheumdis-2017-eular.3019
Abstract: Background Improving and preserving patient (pt) physical function is an important goal for psoriatic arthritis (PsA). Objectives To evaluate apremilast's (APR) effects on physical function/functional status for up to 3 yrs in DMARD/biologic-experienced (PALACE 1–3… read more here.
Keywords: celgene corporation; disability; roche; pfizer ... See more keywords
SAT0448 Apremilast treatment and long-term (up to 156 weeks) improvements in dactylitis and enthesitis in patients with psoriatic arthritis: analysis of a large database of the phase iii clinical development program
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DOI: 10.1136/annrheumdis-2017-eular.3821
Abstract: Background Dactylitis and enthesitis, hallmark features of psoriatic arthritis (PsA), may be difficult to manage. PALACE 1, 2, and 3 compared the efficacy and safety of apremilast (APR) with placebo (PBO) in patients (pts) with… read more here.
Keywords: enthesitis; pfizer; dactylitis; celgene corporation ... See more keywords
OP0082 Apremilast for behÇet’s syndrome: a phase iii randomised, placebo-controlled, double-blind study (RELIEF)
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DOI: 10.1136/annrheumdis-2018-eular.5627
Abstract: Background Oral ulcers (OU) are the most common sign of Behçet’s syndrome (BS) and are observed in nearly every patient. Due to their severity and frequency of reoccurrence, OU can be disabling and have a… read more here.
Keywords: celgene corporation; resolution; treatment; study ... See more keywords
AB0776 RATES OF MYOCARDIAL INFARCTION, STROKE AND REVASCULARIZATION AMONG PATIENTS WITH PSORIATIC ARTHRITIS TREATED WITH APREMILAST, BIOLOGICS, DMARDS AND CORTICOSTEROIDS IN THE US MARKETSCAN DATABASE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.780
Abstract: Background: Patients with psoriatic arthritis (PsA) are at increased risk for cardiovascular events, but different treatment options may not have the same rates of cardiovascular events.1,2 Objectives: To compare rates of myocardial infarction (MI), stroke… read more here.
Keywords: obds corticosteroids; anti tnf; celgene corporation; tnf biologics ... See more keywords
FRI0352 PROBABILITY OF ACHIEVING LOW DISEASE ACTIVITY OR REMISSION WITH APREMILAST TREATMENT AMONG DMARD-NAIVE SUBJECTS WITH ACTIVE PSORIATIC ARTHRITIS
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DOI: 10.1136/annrheumdis-2020-eular.1530
Abstract: Apremilast (APR) is associated with comparable ACR response rates in DMARD-naive vs DMARD-experienced patients (pts) with psoriatic arthritis (PsA).1,2A question that remains is if DMARD-naive pts treated with APR have greater chances of achieving treatment… read more here.
Keywords: grant research; corporation; celgene corporation; research support ... See more keywords
AB0481 EFFICACY OF APREMILAST FOR THE TREATMENT OF GENITAL ULCERS ASSOCIATED WITH ACTIVE BEHÇET’S SYNDROME: A COMBINED ANALYSIS OF TWO RANDOMIZED CONTROLLED TRIALS
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DOI: 10.1136/annrheumdis-2020-eular.2203
Abstract: Background: Behcet’s syndrome is a chronic, multi-system inflammatory disorder characterized by painful, recurrent oral ulcers (OU) and genital ulcers (GU).1 The GU associated with Behcet’s syndrome can contribute to difficulties with sexual activity, walking, and… read more here.
Keywords: employment; study; time; celgene corporation ... See more keywords
Chromothripsis and Chromoplexy Are Associated with DNA Instability and Adverse Clinical Outcome in Multiple Myeloma
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DOI: 10.1182/blood-2018-99-117359
Abstract: Introduction: Chromothripsis and chromoplexy are gross structural events that deregulate multiple genes simultaneously and may help explain rapid changes in clinical behavior. Previous screening studies in multiple myeloma (MM) using copy number arrays have identified… read more here.
Keywords: consultancy honoraria; corporation employment; chromothripsis; celgene corporation ... See more keywords
Clustering of Transcriptomic Signatures in Newly Diagnosed Diffuse Large B-Cell Lymphoma Identifies Two High-Risk Subgroups Which Increase in Prevalence at Relapse
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DOI: 10.1182/blood-2019-122756
Abstract: Background: DLBCL has traditionally been classified by cell of origin (COO) subcategories based on tumor gene expression profiles which include Activated B-Cell (ABC) and Germinal Center B-Cell (GCB). Recently, using tumor samples from patients treated… read more here.
Keywords: research funding; research; corporation employment; celgene corporation ... See more keywords
A Global Systematic Literature Review on the Burden of Illness in Transfusion-Dependent β-Thalassemia
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DOI: 10.1182/blood-2019-124307
Abstract: Introduction: Adults with transfusion-dependent (TD) anemia due to β-thalassemia experience significant side effects and increased mortality due to iron overload resulting from repeated red blood cell (RBC) transfusions. To characterize the burden associated with TD… read more here.
Keywords: thalassemia; celgene corporation; transfusion; burden ... See more keywords