Key role for inhibins in effective T cell activation, migration and Th17 differentiation.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS open bio"
DOI: 10.1002/2211-5463.70106
Abstract: Our group has previously reported that inhibin and its molecular pair, TGF‐β type III receptor (TβRIII), regulate T cell development within the thymus. In addition, inhibins play a key role in immune tolerance through the… read more here.
Keywords: differentiation; role; cell activation; cell ... See more keywords
Cell-Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen-Presenting Cells for T Cell Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801188
Abstract: Biomaterial properties that modulate T cell activation, growth, and differentiation are of significant interest in the field of cellular immunotherapy manufacturing. In this work, a new platform technology that allows for the modulation of various… read more here.
Keywords: lipid bilayers; cell activation; supported lipid; activation ... See more keywords
Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200978
Abstract: Graft‐versus‐host disease (GVHD) is a major life‐threatening complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Inflammatory signaling pathways promote T‐cell activation and are involved in the pathogenesis of GVHD. Suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: gvhd; cell activation; analysis; graft versus ... See more keywords
Increases in 4‐Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8+ T Cell Activation and Allow Tumor Immune Escape
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403629
Abstract: Certain metabolites in the tumor microenvironment (TME) can alter innate immunity. Here, it is shown how phosphomevalonate kinase (PMVK) allows hepatocellular carcinoma (HCC) cells to overcome the anti‐tumor immunity mediated by CD8+ T cells. In… read more here.
Keywords: cell activation; tumor; cd8 cell;
Atopic Multimorbidity in Adults With a Focus on Sensitization Patterns and T Cell Activation
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.70129
Abstract: ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), asthma (AA), and allergic rhinitis (AR)—are driven by Th2 inflammation and often occur together (atopic multimorbidity), along with non‐atopic comorbidities. Chronic spontaneous urticaria (CSU) is an autoimmune mast… read more here.
Keywords: cell activation; atopic; atopic multimorbidity; atopic diseases ... See more keywords
Targeting glycogen synthase kinase 3 with CHIR99021 negatively regulates allergen‐induced mast cell activation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250104
Abstract: Mast cells are granulated immune sentinels responsible for allergic inflammation. Allergen‐induced FcεRI‐signaling leads to rapid degranulation in the early‐phase and sustained production and release of pro‐inflammatory mediators in the late phase. Glycogen synthase kinase 3… read more here.
Keywords: cell activation; allergen induced; mast cell; mast ... See more keywords
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23151
Abstract: To unveil the role and regulatory mechanism of miR‐146a‐5p in sepsis. A sepsis cell model was established via lipopolysaccharide (LPS)‐induction in dendritic cells (DCs). The maturation of DCs was evaluated via flow cytometry. Gene expression… read more here.
Keywords: mir 146a; cell activation; sepsis;
T cell activation contributes to purifying selection against the MELAS‐associated m.3243A>G pathogenic variant in blood
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12726
Abstract: T cells have been shown to maintain a lower percentage (heteroplasmy) of the pathogenic m.3243A>G variant (MT‐TL1, associated with maternally inherited diabetes and deafness [MIDD] and mitochondrial encephalomyopathy with lactic acidosis and stroke‐like episodes [MELAS]).… read more here.
Keywords: cell activation; heteroplasmy; selection; purifying selection ... See more keywords
Neuroserpin regulates human T cell‐T cell interactions and proliferation through inhibition of tissue plasminogen activator
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2a1019-098rr
Abstract: T cells play a key role in mounting an adaptive immune response. T cells are activated upon recognition of cognate Ag presented by an APC. Subsequently, T cells adhere to other activated T cells to… read more here.
Keywords: activation; biology; cell activation; proliferation ... See more keywords
Heparanase is a regulator of natural killer cell activation and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3a0420-259rr
Abstract: Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces. Most immune cells express heparanase that contributes to a range of functions including cell migration… read more here.
Keywords: cytotoxicity; cell activation; heparanase; hpse ... See more keywords
The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE‐mediated mast cell activation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0320-547rr
Abstract: Mast cell activation through the high‐affinity IgE receptor (FcεRI) plays a central role in allergic reactions. FcεRI‐mediated activation triggers multiple signaling pathways leading to degranulation and synthesis of different inflammatory mediators. IgE‐mediated mast cell activation… read more here.
Keywords: mast cell; cell activation; cell; ige mediated ... See more keywords