Cell-Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen-Presenting Cells for T Cell Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801188
Abstract: Biomaterial properties that modulate T cell activation, growth, and differentiation are of significant interest in the field of cellular immunotherapy manufacturing. In this work, a new platform technology that allows for the modulation of various… read more here.
Keywords: lipid bilayers; cell activation; supported lipid; activation ... See more keywords
Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease
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DOI: 10.1002/advs.202200978
Abstract: Graft‐versus‐host disease (GVHD) is a major life‐threatening complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Inflammatory signaling pathways promote T‐cell activation and are involved in the pathogenesis of GVHD. Suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: gvhd; cell activation; analysis; graft versus ... See more keywords
Targeting glycogen synthase kinase 3 with CHIR99021 negatively regulates allergen‐induced mast cell activation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250104
Abstract: Mast cells are granulated immune sentinels responsible for allergic inflammation. Allergen‐induced FcεRI‐signaling leads to rapid degranulation in the early‐phase and sustained production and release of pro‐inflammatory mediators in the late phase. Glycogen synthase kinase 3… read more here.
Keywords: cell activation; allergen induced; mast cell; mast ... See more keywords
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23151
Abstract: To unveil the role and regulatory mechanism of miR‐146a‐5p in sepsis. A sepsis cell model was established via lipopolysaccharide (LPS)‐induction in dendritic cells (DCs). The maturation of DCs was evaluated via flow cytometry. Gene expression… read more here.
Keywords: mir 146a; cell activation; sepsis;
Neuroserpin regulates human T cell‐T cell interactions and proliferation through inhibition of tissue plasminogen activator
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2a1019-098rr
Abstract: T cells play a key role in mounting an adaptive immune response. T cells are activated upon recognition of cognate Ag presented by an APC. Subsequently, T cells adhere to other activated T cells to… read more here.
Keywords: activation; biology; cell activation; proliferation ... See more keywords
Heparanase is a regulator of natural killer cell activation and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3a0420-259rr
Abstract: Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces. Most immune cells express heparanase that contributes to a range of functions including cell migration… read more here.
Keywords: cytotoxicity; cell activation; heparanase; hpse ... See more keywords
The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE‐mediated mast cell activation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0320-547rr
Abstract: Mast cell activation through the high‐affinity IgE receptor (FcεRI) plays a central role in allergic reactions. FcεRI‐mediated activation triggers multiple signaling pathways leading to degranulation and synthesis of different inflammatory mediators. IgE‐mediated mast cell activation… read more here.
Keywords: mast cell; cell activation; cell; ige mediated ... See more keywords
Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.6985
Abstract: Persimmon leaf extracts (PLE) have been widely used as a traditional medicine in East Asian countries. The effects of persimmon leaves, including antioxidant, antiinflammatory, hypotensive, and anti‐allergy effects, have been investigated; however, there is little… read more here.
Keywords: atopic dermatitis; persimmon leaf; activation via; cell activation ... See more keywords
Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202200925
Abstract: Immune intervention of B cell activation to blockade the production of autoantibodies provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy development. Although the survival rate for SLE is improved, many patients… read more here.
Keywords: engineered cell; cell; cell membrane; cd40 nvs ... See more keywords
Use of Streptolysin O-Induced Membrane Damage as a Method of Studying the Function of Lipid Rafts During B Cell Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_17
Abstract: B-lymphocytes have the ability to repair their plasma membranes following injury, such as by bacterial cholesterol-dependent cytolysins. The repair process includes the removal of the pore from the inflicted region of the plasma membrane via… read more here.
Keywords: rafts cell; method; use streptolysin; cell activation ... See more keywords
Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-49844-3_6
Abstract: Protein kinase C (PKCs) isoforms play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion, etc. Patterns of expression for each PKC isoform differ among… read more here.
Keywords: immune cell; implication; cell activation; role ... See more keywords