DEX-Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T-Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202205854
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant blood disorder with a high rate of relapse. Patients relapse as a result of minimal residual disease (MRD), which originates from residual T-ALL cells in the… read more here.
Keywords: cell; leukemia; dex; acute lymphoblastic ... See more keywords
Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia‐derived cells: Role of PKCβ
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DOI: 10.1002/ardp.202000062
Abstract: In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia‐derived cell line, CCRF‐CEM. On the basis of the structural features… read more here.
Keywords: cell acute; lymphoblastic leukemia; acute lymphoblastic; leukemia derived ... See more keywords
Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia
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DOI: 10.1002/cac2.12080
Abstract: T‐cell acute lymphoblastic leukemia (T‐ALL) is an uncommon and aggressive subtype of acute lymphoblastic leukemia (ALL). In the serum of T‐ALL patients, the activity of lactate dehydrogenase A (LDHA) is increased. We proposed that targeting… read more here.
Keywords: cell acute; lymphoblastic leukemia; acute lymphoblastic; lactate dehydrogenase ... See more keywords
TNFAIP3 mutation is an independent poor overall survival factor for patients with T‐cell acute lymphoblastic leukemia
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DOI: 10.1002/cam4.5196
Abstract: It is imperative to explore potential biomarkers for predicting clinical outcome and developing targeted therapies for T‐cell acute lymphoblastic leukemia (T‐ALL). This study aimed to investigate the mutation patterns of tumor necrosis factor‐alpha‐inducing protein 3… read more here.
Keywords: factor; lymphoblastic leukemia; acute lymphoblastic; cell acute ... See more keywords
Low leukemia burden improves blinatumomab efficacy in patients with relapsed/refractory B‐cell acute lymphoblastic leukemia
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DOI: 10.1002/cncr.34667
Abstract: A lower baseline bone marrow blast percentage (bBMB%) is associated with better outcomes in patients with B‐cell acute lymphoblastic leukemia (B‐ALL) receiving blinatumomab. The objective of this analysis was to investigate the association between bBMB%… read more here.
Keywords: relapsed refractory; low leukemia; leukemia; lymphoblastic leukemia ... See more keywords
Aggressive Langerhans cell histiocytosis transformation of T cell acute lymphoblastic leukemia detected on 18F-FDG PET/CT
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04872-1
Abstract: A 12-year-old boy with clinical history of T cell acute lymphoblastic leukemia (T-ALL) 10 months ago presented with multiple palpable and enlarged left cervical lymph nodes, splenomegaly, and fatigue for 1 month. Bonemarrow biopsy result… read more here.
Keywords: langerhans cell; cell acute; fdg pet; transformation ... See more keywords
Rapidly ascending necrotizing myelopathy with widespread brain white matter involvement following intrathecal methotrexate and cytosine arabinoside treatment in an adult with T cell acute lymphoblastic leukemia
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DOI: 10.1007/s10072-018-3435-x
Abstract: Dear Editor, In this paper we described a case of a 53-year-old man, admitted to the hematology ward due to fatigue, dyspnea, and severe hyper-leukocytosis (WBC 356 × 10/l), diagnosed with T cell acute lymphoblastic… read more here.
Keywords: cell acute; methotrexate; treatment; acute lymphoblastic ... See more keywords
Evaluating the expression level of Survivin gene in different groups of B-cell acute lymphoblastic leukemia patients of Iran
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DOI: 10.1007/s11033-019-04703-z
Abstract: Survivin is one of the major members of Inhibitory Apoptotic Proteins (IAP) family. The functional anti-apoptotic and regulatory role of Survivin in the cell cycle had made it as an interesting candidate for tumor studies.… read more here.
Keywords: cell acute; lymphoblastic leukemia; expression; acute lymphoblastic ... See more keywords
DT7 peptide-modified lecithin nanoparticles co-loaded with γ-secretase inhibitor and dexamethasone efficiently inhibit T-cell acute lymphoblastic leukemia and reduce gastrointestinal toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer letters"
DOI: 10.1016/j.canlet.2022.215608
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a serious hematologic malignancy and glucocorticoid resistance is the main recurrent cause for a high relapsed and death rate. Here, we proposed an effective therapeutic regimen of combining gamma-secretase… read more here.
Keywords: cell acute; peptide modified; dt7 peptide; leukemia ... See more keywords
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival
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DOI: 10.1016/j.htct.2019.09.005
Abstract: Background and objective T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy.… read more here.
Keywords: cell acute; treatment; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
A clinical perspective on immunoglobulin heavy chain clonal heterogeneity in B cell acute lymphoblastic leukemia.
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DOI: 10.1016/j.leukres.2018.10.018
Abstract: B cell acute lymphoblastic leukemia (B ALL) is a genetically heterogeneous neoplasm often demonstrating extensive subclone diversity within each patient's disease. The immunoglobulin heavy chain (IGH) locus is a marker of clonal variation in B… read more here.
Keywords: cell acute; cell; lymphoblastic leukemia; acute lymphoblastic ... See more keywords