Opportunities and Challenges in Stem Cell Aging.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_624
Abstract: Studying aging, as a physiological process that can cause various pathological phenotypes, has attracted lots of attention due to its increasing burden and prevalence. Therefore, understanding its mechanism to find novel therapeutic alternatives for age-related… read more here.
Keywords: challenges stem; cell aging; stem cell; opportunities challenges ... See more keywords
T-cell aging in end-stage renal disease: an evolving story with CMV
Sign Up to like & getrecommendations! Published in 2019 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-019-00596-8
Abstract: Established evidence from the last decade has suggested that chronic cytomegalovirus infection has strong impact on the human immune system, resulting in aggravated aging-associated T-cell changes that are associated with poorer vaccination responses, cardiovascular disease… read more here.
Keywords: renal disease; stage renal; disease; cell aging ... See more keywords
Regulation of Stem Cell Aging by Metabolism and Epigenetics.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.07.019
Abstract: Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated declines in stem cell function are characterized by metabolic and epigenetic changes. Understanding the mechanisms underlying these changes will likely reveal novel… read more here.
Keywords: metabolism; cell aging; stem cell; stem ... See more keywords
Germline stem cell aging in the Drosophila ovary.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2019.11.003
Abstract: The age-related decline of adult stem cells leads to loss of tissue homeostasis and contributes to organismal aging. Though the phenotypic hallmarks of aging are well-characterized at the organ or tissue level, the molecular processes… read more here.
Keywords: drosophila ovary; stem cell; aging drosophila; cell aging ... See more keywords
Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.04.005
Abstract: ABSTRACT Changes in mitochondrial structure and function are the initial factors of cell aging. Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear. In this study, mouse neuroblastoma… read more here.
Keywords: cell aging; gal treatment; spermidine; n2a cells ... See more keywords
Effects of module stiffness and initial compression on lithium-ion cell aging
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Power Sources"
DOI: 10.1016/j.jpowsour.2021.230163
Abstract: Abstract The effects of automotive-related lithium-ion module design, i.e. module stiffness and initial compression during module assembly on cell aging, swelling and pressure evolution are still largely unknown. This paper presents the results of a… read more here.
Keywords: stiffness initial; cell aging; cell; lithium ion ... See more keywords
miRNAs in stem cell aging and age-related disease
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2017.08.013
Abstract: MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of mRNA targets and play a part in the post-transcriptional silencing. To date, the prominent roles of miRNAs in stem cells have been investigated in… read more here.
Keywords: age; cell aging; stem cell; stem ... See more keywords
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111254
Abstract: Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged… read more here.
Keywords: cell aging; stem cell; checkpoint; stem ... See more keywords
Childhood poverty, immune cell aging, and African Americans' insulin resistance: A prospective study
Sign Up to like & getrecommendations! Published in 2022 at "Child Development"
DOI: 10.1111/cdev.13795
Abstract: Abstract The present study investigated developmental pathways that can contribute to chronic disease among rural African Americans. With a sample of 342 African American youth (59% female) from the southeastern United States followed for nearly… read more here.
Keywords: immune cell; insulin resistance; african americans; poverty ... See more keywords
Oxidative Stress in Stem Cell Aging
Sign Up to like & getrecommendations! Published in 2017 at "Cell Transplantation"
DOI: 10.1177/0963689717735407
Abstract: Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages… read more here.
Keywords: oxidative stress; stem cell; cell; cell aging ... See more keywords
Hematopoietic Stem Cell Aging and Leukemia Transformation.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022017933
Abstract: With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate, differentiate, and produce the entire repertoire of mature blood and immune cells. Due to dysfunctional hematopoiesis, the incidence of hematologic malignancies increases in… read more here.
Keywords: stem cell; aging leukemia; transformation; hematopoietic stem ... See more keywords