The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Clinical Pharmacology"
DOI: 10.1002/bcp.70071
Abstract: Abstract Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected children… read more here.
Keywords: hydroxyurea children; children sickle; cell anaemia; dosing hydroxyurea ... See more keywords
Faith Healing Techniques in the Management of Sickle Cell Anaemia in Nigeria
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DOI: 10.1007/s40609-023-00323-5
Abstract: People living with sickle cell anaemia (SCA) tend to experience multiple sources of therapy complemented by self-care practices. In Nigeria, over 100,000 babies are born yearly with sickle cell anaemia. High prevalence of this disease… read more here.
Keywords: treatment; cell anaemia; medicine; faith healing ... See more keywords
Cholelithiasis in patients with paediatric sickle cell anaemia in a Saudi hospital
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2019.02.007
Abstract: Objective Sickle cell disease is one of the most common inherited hemoglobinopathies in the world. Chronic haemolysis predisposes individuals to the development of bilirubinate cholelithiasis, which can be asymptomatic or can result in cholecystitis, choledocholithiasis,… read more here.
Keywords: cell anaemia; patients paediatric; sickle cell; cholelithiasis ... See more keywords
Allele-specific recombinase polymerase amplification for real-time detection of sickle cell anaemia in low-resource settings: evaluation of an isothermal nucleic acid amplification test to detect the βS globin point mutation in paediatric patients
Sign Up to like & getrecommendations! Published in 2021 at "The Lancet Global Health"
DOI: 10.1016/s2214-109x(21)00121-2
Abstract: Abstract Background Sickle cell anaemia is a common, life-threatening disorder caused by a point mutation in the β globin gene. The high cost and complexity of conventional diagnostic methods limit the scope and sustainability of… read more here.
Keywords: blood; cell anaemia; globin; amplification ... See more keywords
Predictors of impending acute chest syndrome in patients with sickle cell anaemia
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DOI: 10.1038/s41598-020-59258-y
Abstract: Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS… read more here.
Keywords: sickle cell; cell anaemia; acute chest; chest syndrome ... See more keywords
Pulmonary hypertension and right ventricular function in Nigerian children with sickle cell anaemia
Sign Up to like & getrecommendations! Published in 2019 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/trz038
Abstract: Abstract Background Pulmonary hypertension (PH), a complication of sickle cell anaemia (SCA), results in considerable morbidity. This study aims to determine the prevalence and associations of echocardiography-suggested PH in children with SCA. Methods We performed… read more here.
Keywords: ventricular function; pulmonary hypertension; right ventricular; cell anaemia ... See more keywords
Clinical and genetic factors are associated with kidney complications in African children with sickle cell anaemia.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of haematology"
DOI: 10.1111/bjh.17832
Abstract: Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease… read more here.
Keywords: genetic factors; clinical genetic; cell anaemia; cell ... See more keywords
Sickle cell anaemia therapy in 2025
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DOI: 10.1111/bjh.19933
Abstract: New pharmacological therapies for sickle cell anaemia have not been as efficacious as hoped, while widespread application of curative stem cell and gene therapies is not likely to occur soon. This situation raises the question… read more here.
Keywords: anaemia therapy; cell; therapy 2025; cell anaemia ... See more keywords
Cerebral blood flow trajectories in paediatric sickle cell anaemia by age, region, and treatment associations.
Sign Up to like & getrecommendations! Published in 2025 at "British journal of haematology"
DOI: 10.1111/bjh.70224
Abstract: Opposite to the age trend in healthy children, cerebral blood flow increases with age in children with sickle cell anaemia. Early treatment with hydroxyurea (hydroxycarbamide) may help slow this abnormal trend and protect brain functions. read more here.
Keywords: age; blood flow; cell anaemia; sickle cell ... See more keywords
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Haematology"
DOI: 10.1111/ejh.13212
Abstract: Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is poorly soluble when deoxygenated, and when this is prolonged,… read more here.
Keywords: pathophysiology; cell anaemia; sickle; cell ... See more keywords
G112(P) Lung function in paediatric subjects with sickle cell anaemia: A comparison between UK and Italy
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-313087.111
Abstract: Background respiratory morbidity is common in patients with sickle cell anaemia (SCA). The quality of care and environmental factors might have an influence on their respiratory health. Aims to compare spirometry lung function in children… read more here.
Keywords: italy; spirometry; cell anaemia; cell ... See more keywords