Changes in Hydroxyurea Use Among Youths Enrolled in Medicaid With Sickle Cell Anemia After 2014 Revision of Clinical Guidelines.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2023.4584
Abstract: Importance Youths with sickle cell anemia (SCA) are at risk of pain crises, stroke, and early death. Complications can be reduced by the oral disease-modifying medication hydroxyurea, and in 2014, the National Heart, Lung, and… read more here.
Keywords: cell anemia; changes hydroxyurea; use; among youths ... See more keywords
Losartan for the nephropathy of sickle cell anemia: A phase‐2, multicenter trial
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24810
Abstract: Nephropathy is a common and progressive complication of sickle cell anemia (SCA). In SCA mice, we found that hyperangiotensinemia in the absence of hypertension underlies nephropathy, and its downregulation by losartan, an angiotensin‐II‐receptor‐1 blocker, reduced… read more here.
Keywords: trial; losartan nephropathy; losartan; cell anemia ... See more keywords
Longitudinal effect of disease‐modifying therapy on left ventricular diastolic function in children with sickle cell anemia
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26911
Abstract: Cardiac abnormalities seen in sickle cell anemia (SCA) include diastolic dysfunction, which has been shown to be associated with high morbidity and early mortality. The effect of disease‐modifying therapies (DMT) on diastolic dysfunction is poorly… read more here.
Keywords: function; cell anemia; effect disease; sickle cell ... See more keywords
Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22140
Abstract: The influence of phenotype on the clinical course and laboratory features of sickle cell anemia (SCA) is rarely described in sub‐Saharan Africa. read more here.
Keywords: phenotypes biological; biological parameters; clinical phenotypes; cell anemia ... See more keywords
Validity of simple clinical and biological parameters as screening tool for sickle cell anemia for referral to tertiary center in highly resource constraints
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22145
Abstract: In the Democratic Republic of Congo, the incidence of sickle cell anemia (SCA) is estimated around 40 000 neonates per year. However, it is notoriously difficult to perform conventional electrophoresis in all hospitals and laboratories,… read more here.
Keywords: highly resource; validity simple; cell anemia; sickle ... See more keywords
Trace elements in children suffering from sickle cell anemia: A case–control study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22160
Abstract: Information on serum albumin and trace elements among children suffering from Sickle Cell Anemia (SCA) was poorly documented in Africa. The aim of this study was to describe and to compare different values of trace… read more here.
Keywords: suffering sickle; cell anemia; children suffering; trace elements ... See more keywords
DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24398
Abstract: Hemoglobin‐based tests form the reference diagnostic test for SCA. In limited resource countries, these tests face limitations including cost, low sensitivity due to recurrent transfusions in endemic malaria region, and interference from fetal hemoglobin in… read more here.
Keywords: cell anemia; dna; anemia africa; testing sickle ... See more keywords
Evaluation of bone mineral density in children with sickle-cell anemia and its associated factors in the south of Iran: a case-control study
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DOI: 10.1007/s11657-017-0364-x
Abstract: SummarySickle-cell anemia is a hereditary hemoglobin disorder among children. We showed that the low bone mass is prevalent among these children, and it has a negative association with hemoglobin. In spite of using supplementary 200 IU/day… read more here.
Keywords: children sickle; cell anemia; cell; evaluation bone ... See more keywords
Melatonin as an alternative and promising therapy for people with sickle cell anemia
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.317
Abstract: This study investigated possible modulatory effects of melatonin treatment on red blood cell (RBC) metabolism in an auto incubation model. The study was carried out on six healthy donors (REF) and six sickle cell anemia… read more here.
Keywords: treatment; cell anemia; melatonin; cell ... See more keywords
Using novel magnetic resonance imaging methods to predict stroke risk in individuals with sickle cell anemia.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2019.12.009
Abstract: Sickle cell anemia (SCA) is a well-characterized monogenetic disorder with a high prevalence of cerebral vasculopathy, silent cerebral infarcts, and strokes. A significant mechanism for cerebral infarction in SCA is hemodynamic imbalance. To compensate for… read more here.
Keywords: resonance imaging; magnetic resonance; cell anemia; cell ... See more keywords
Craniofacial geometric morphometrics in the identification of patients with sickle cell anemia and sickle cell trait
Sign Up to like & getrecommendations! Published in 2019 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2019.10.003
Abstract: Objective The aims of this study were to identify the main characteristics regarding the shape and size of the craniofacial region in patients with sickle cell anemia (SCA) and sickle cell trait (SCT) and in… read more here.
Keywords: geometric morphometrics; patients sickle; analysis; cell anemia ... See more keywords