Actinin‐4 controls survival signaling in B cells by limiting the lateral mobility of B‐cell antigen receptors
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350774
Abstract: The structure and dynamics of F‐actin networks in the cortical area of B cells control the signal efficiency of B‐cell antigen receptors (BCRs). Although antigen‐induced signaling has been studied extensively, the role of cortical F‐actin… read more here.
Keywords: antigen; cell; antigen receptors; cortical actin ... See more keywords
Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_12
Abstract: The B cell antigen receptor (BCR) is found to be non-randomly organized at nano-scale distances on the B cell surface. Studying the organization and relocalization of the BCR is thus likely to provide new clues… read more here.
Keywords: cell antigen; cell; situ fab; nano scale ... See more keywords
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109375
Abstract: Summary The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable… read more here.
Keywords: tcr cd3; cd3; antigen receptor; cell antigen ... See more keywords
The role of stem cell antigen-1/Lymphocyte antigen 6A-2/6E-1 knock out in murine epidermis.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.102047
Abstract: Stem Cell Antigen-1 (SCA-1) is a central positive marker for isolating stem cells in several tissues in the mouse. However, for the epidermis, this appears to be the opposite since lack of SCA-1 has been… read more here.
Keywords: stem cell; antigen; sca knockout; cell antigen ... See more keywords
Generation of Allogeneic CAR T Cells through Specific Degradation of the T Cell Antigen Receptor by E3 Ubiquitin Ligase Fusion Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00397
Abstract: Receptor downregulation is instrumental for many therapeutic interventions. Receptor knockout through gene-editing technologies is efficient but can introduce off-target mutations and chromothripsis. Regulation of gene expression at the protein level is a promising alternative. Here,… read more here.
Keywords: fusion; car; degradation; receptor ... See more keywords
A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1907481116
Abstract: Significance The specific activation of B lymphocytes via the binding of antigen to their B cell antigen receptor (BCR) is of central importance for the establishment of humoral immunity and a successful vaccination. A better… read more here.
Keywords: cell antigen; bcr; molecule; geometry ... See more keywords
Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2
Sign Up to like & getrecommendations! Published in 2018 at "Glycobiology"
DOI: 10.1093/glycob/cwy050
Abstract: Abstract Blood dendritic cell antigen 2 (BDCA-2) is a C-type lectin found on the surface of plasmacytoid dendritic cells. It functions as a glycan-binding receptor that downregulates the production of type I interferons and thus… read more here.
Keywords: cell antigen; blood dendritic; glycoprotein ligands; serum ... See more keywords
Broad-Spectrum Defenders: γδ T Cells Take on a Multitude of Immune Challenges.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae044
Abstract: In a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather,… read more here.
Keywords: cell antigen; broad spectrum; cells take; defenders cells ... See more keywords
The role of B cell antigen presentation in the initiation of CD4+ T cell response
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Reviews"
DOI: 10.1111/imr.12859
Abstract: B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood.… read more here.
Keywords: cell antigen; response; antigen presentation; cell ... See more keywords
Flotillin-2 dampens T cell antigen sensitivity and functionality
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.182328
Abstract: T cell receptor (TCR) engagement triggers T cell responses, yet how TCR-mediated activation is regulated at the plasma membrane remains unclear. Here, we report that deleting the membrane scaffolding protein Flotillin-2 (Flot2) increases T cell… read more here.
Keywords: antigen sensitivity; weak tcr; cell; sensitivity ... See more keywords
Corrigendum: Exploring the interaction between T-cell antigen receptor-related genes and MAPT or ACHE using integrated bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1204487
Abstract: [This corrects the article DOI: 10.3389/fneur.2023.1129470.]. read more here.
Keywords: corrigendum exploring; antigen receptor; receptor related; interaction cell ... See more keywords