Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_12
Abstract: The B cell antigen receptor (BCR) is found to be non-randomly organized at nano-scale distances on the B cell surface. Studying the organization and relocalization of the BCR is thus likely to provide new clues… read more here.
Keywords: cell antigen; cell; situ fab; nano scale ... See more keywords
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109375
Abstract: Summary The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable… read more here.
Keywords: tcr cd3; cd3; antigen receptor; cell antigen ... See more keywords
The role of stem cell antigen-1/Lymphocyte antigen 6A-2/6E-1 knock out in murine epidermis.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.102047
Abstract: Stem Cell Antigen-1 (SCA-1) is a central positive marker for isolating stem cells in several tissues in the mouse. However, for the epidermis, this appears to be the opposite since lack of SCA-1 has been… read more here.
Keywords: stem cell; antigen; sca knockout; cell antigen ... See more keywords
Generation of Allogeneic CAR T Cells through Specific Degradation of the T Cell Antigen Receptor by E3 Ubiquitin Ligase Fusion Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00397
Abstract: Receptor downregulation is instrumental for many therapeutic interventions. Receptor knockout through gene-editing technologies is efficient but can introduce off-target mutations and chromothripsis. Regulation of gene expression at the protein level is a promising alternative. Here,… read more here.
Keywords: fusion; car; degradation; receptor ... See more keywords
A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1907481116
Abstract: Significance The specific activation of B lymphocytes via the binding of antigen to their B cell antigen receptor (BCR) is of central importance for the establishment of humoral immunity and a successful vaccination. A better… read more here.
Keywords: cell antigen; bcr; molecule; geometry ... See more keywords
Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2
Sign Up to like & getrecommendations! Published in 2018 at "Glycobiology"
DOI: 10.1093/glycob/cwy050
Abstract: Abstract Blood dendritic cell antigen 2 (BDCA-2) is a C-type lectin found on the surface of plasmacytoid dendritic cells. It functions as a glycan-binding receptor that downregulates the production of type I interferons and thus… read more here.
Keywords: cell antigen; blood dendritic; glycoprotein ligands; serum ... See more keywords
The role of B cell antigen presentation in the initiation of CD4+ T cell response
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Reviews"
DOI: 10.1111/imr.12859
Abstract: B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood.… read more here.
Keywords: cell antigen; response; antigen presentation; cell ... See more keywords
Corrigendum: Exploring the interaction between T-cell antigen receptor-related genes and MAPT or ACHE using integrated bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1204487
Abstract: [This corrects the article DOI: 10.3389/fneur.2023.1129470.]. read more here.
Keywords: corrigendum exploring; antigen receptor; receptor related; interaction cell ... See more keywords
Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119420
Abstract: Prostate specific membrane antigen (PSMA) is an excellent target for imaging and treatment of prostate carcinoma (PCa). Unfortunately, not all PCa cells express PSMA. Therefore, alternative theranostic targets are required. The membrane protein prostate stem… read more here.
Keywords: antigen psca; stem cell; prostate; prostate stem ... See more keywords