Managing Treatment‐Emergent Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CAR‐T Cell Therapy: A Case‐Based Review of the use of Emapalumab
Sign Up to like & getrecommendations! Published in 2025 at "Hematological Oncology"
DOI: 10.1002/hon.70157
Abstract: ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapies have revolutionized the treatment of hematological malignancies, achieving high response rates in patients with relapsed or refractory disease. Despite these benefits, CAR‐T cell therapies are associated with… read more here.
Keywords: immune effector; therapy; car cell; cell associated ... See more keywords
Current treatment options of T cell-associated immunotherapy in multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-017-0450-9
Abstract: Multiple myeloma (MM) is a complex disease and is presently an incurable malignant plasma cell tumor. Although the introduction of proteasome inhibitor and the immunomodulators markedly improved the effect of myeloma therapy, most patients still… read more here.
Keywords: myeloma; options cell; cell associated; treatment options ... See more keywords
Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.06.038
Abstract: Summary Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells. In vitro polymerized F-actin can be used… read more here.
Keywords: dngr; cell associated; associated antigens; cross presentation ... See more keywords
Cell-free DNA: A Neglected Source for Antibiotic Resistance Genes Spreading from WWTPs.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b04283
Abstract: Cell-associated ARGs in wastewater treatment plants (WWTPs) has been concerned, however, cell-free ARGs in WWTPs was rarely studied. In this study, the abundances of four representative ARGs, sulII, tetC, blaPSE-1, and ermB, in a large… read more here.
Keywords: cell associated; associated args; cell free; free args ... See more keywords
Goblet Cell Associated Antigen Passages are Inhibited During Salmonella typhimurium Infection to Prevent Pathogen Dissemination and Limit Responses to Dietary Antigens
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0007-6
Abstract: Dietary antigen acquisition by lamina propria (LP) dendritic cells (DCs) is crucial to induce oral tolerance and maintain homeostasis. However, encountering innocuous antigens during infection can lead to inflammatory responses, suggesting processes may limit steady-state… read more here.
Keywords: pathogen; cell associated; infection; antigen ... See more keywords
Multifocal demyelinating leukoencephalopathy and oligodendroglial lineage cell loss with immune effector cell-associated neurotoxicity syndrome (ICANS) following CD19 CAR T-cell therapy for mantle cell lymphoma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac121
Abstract: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a prevalent condition seen after treatment with chimeric antigen receptor T-cell (CAR T) therapy and other cancer cell therapies. The underlying pathophysiology and neuropathology of the clinical syndrome… read more here.
Keywords: cell; cell associated; therapy; car ... See more keywords
Sex Differences in Mast Cell-Associated Disorders: A Life Span Perspective.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a039172
Abstract: Mast cells are critical innate immune effectors located throughout the body that are crucial for host defense mechanisms via orchestrating immune responses to a variety of host and environmental stimuli necessary for survival. The role… read more here.
Keywords: mast cell; sex differences; cell associated; sex ... See more keywords
Use of Dasatinib for the Treatment of Refractory Immune Effector Cell‐Associated Neurotoxicity Syndrome After Axicabtagene Ciloleucel Infusion: A Case Report
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Haematology"
DOI: 10.1111/ejh.70038
Abstract: Chimeric antigen receptor (CAR) T‐cell therapy is a well‐established approach for refractory hematological malignancies. Cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) remain a major concern of CAR T‐cell therapy, particularly in… read more here.
Keywords: treatment; immune effector; refractory; cell associated ... See more keywords
The Sia System and c-di-GMP Play a Crucial Role in Controlling Cell-Association of Psl in Planktonic P. aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00335-22
Abstract: The biofilm matrix of the opportunistic pathogen Pseudomonas aeruginosa is composed of exopolysaccharides (EPS), proteins, and nucleic acids. In P. aeruginosa, an increase in the small molecule c-di-GMP causes an increase in biofilm matrix production… read more here.
Keywords: system; sia system; cell associated; psl ... See more keywords
SPOT-006 Stem cell-associated heterogeneity in glioblastoma is a result of intrinsic tumour plasticity shaped by the microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.39
Abstract: Introduction To date there is no curative treatment available for patients with Glioblastoma (GBM). The cancer stem cell (CSC) hypothesis posits that GBMs rely on a small subpopulation of cells with stemness properties responsible for… read more here.
Keywords: heterogeneity; cell associated; stem cell; stem ... See more keywords
Single-cell combined bioinformatics analysis: construction of immune cluster and risk prognostic model in kidney renal clear cells based on CD8+ T cell-associated genes
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Medical Research"
DOI: 10.1186/s40001-024-01689-8
Abstract: Kidney cancer is an immunogenic solid tumor, characterized by high tumor burden and infiltration of CD8+ T cells. Although immunotherapy targeting the PD1/CTLA-4 axis has demonstrated excellent clinical efficacy, clinical outcomes in most patients are… read more here.
Keywords: cd8; analysis; cell associated; cell ... See more keywords