Revealing the Critical Regulators of Cell Identity in the Mouse Cell Atlas
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.045
Abstract: SUMMARY Recent progress in single-cell technologies has enabled the identification of all major cell types in mouse. However, for most cell types, the regulatory mechanism underlying their identity remains poorly understood. By computational analysis of… read more here.
Keywords: mouse cell; cell atlas; cell; cell types ... See more keywords
The Organoid Cell Atlas
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-00762-x
Abstract: To the Editor — Human organoids hold tremendous potential for biomedical applications1–3 (Fig. 1a,b). These three-dimensional structures of cultured cells recapitulate important aspects of in vivo organ development and biological function. They provide tractable in… read more here.
Keywords: single cell; cell atlas; biology; human organoids ... See more keywords
Filling in the slate with transcriptomes for mice across ages
Sign Up to like & getrecommendations! Published in 2020 at "Lab Animal"
DOI: 10.1038/s41684-020-0635-9
Abstract: In 2018, an international consortium of researchers began filling in the ‘blank slate’ that was the mouse transcriptome with the Tabula Muris, or Mouse Cell Atlas. Using two different methods for separating cells—fluorescence-activated cell sorting… read more here.
Keywords: mice across; tabula muris; cell atlas; slate ... See more keywords
Cell Atlas technologies and insights into tissue architecture
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.1042/bcj20190341
Abstract: Since Robert Hooke first described the existence of ‘cells’ in 1665, scientists have sought to identify and further characterise these fundamental units of life. While our understanding of cell location, morphology and function has expanded… read more here.
Keywords: atlas technologies; tissue architecture; cell atlas; cell ... See more keywords
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200914119
Abstract: The anterior segment of the eye consists of the cornea, iris, ciliary body, crystalline lens and aqueous humor outflow pathways. Together, these tissues are essential for the proper functioning of the eye. Disorders of vision… read more here.
Keywords: cell; cell atlas; cell types; anterior segment ... See more keywords
The Human Cell Atlas: Technical approaches and challenges
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elx029
Abstract: Abstract The Human Cell Atlas is a large, international consortium that aims to identify and describe every cell type in the human body. The comprehensive cellular maps that arise from this ambitious effort have the… read more here.
Keywords: cell atlas; technical approaches; human cell; atlas technical ... See more keywords
A single-cell atlas of murine reproductive tissues during preterm labor
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.04.27.489704
Abstract: Preterm birth, the leading cause of perinatal morbidity and mortality worldwide, frequently results from the syndrome of preterm labor. Intra-amniotic infection is the best-established causal link to preterm labor, and involves premature activation of the… read more here.
Keywords: preterm labor; cell atlas; labor; single cell ... See more keywords
A single-cell atlas of the normal and malformed human brain vasculature
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abi7377
Abstract: Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to… read more here.
Keywords: cerebrovasculature; single cell; human brain; cell atlas ... See more keywords
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abk2432
Abstract: For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei… read more here.
Keywords: cell; cell atlas; cell types; drosophila ... See more keywords
Open Data in the Era of the GDPR: Lessons from the Human Cell Atlas.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-101322-113255
Abstract: The Human Cell Atlas (HCA) is striving to build an open community that is inclusive of all researchers adhering to its principles and as open as possible with respect to data access and use. However,… read more here.
Keywords: gdpr; cell atlas; human cell; open data ... See more keywords
Knocking Out Smoking and Pulmonary Hypertension with a K+
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202011-4121ed
Abstract: 1. Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, et al. Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Mol Biol Cell 2005;16:2154–2167. 2. Engelhardt JF,… read more here.
Keywords: human lung; human airway; cell atlas; cell ... See more keywords