Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
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DOI: 10.1021/acs.molpharmaceut.2c00768
Abstract: The presence of the blood–brain barrier (BBB) creates a nigh-on impenetrable obstacle for large macromolecular therapeutics that need to be delivered to the brain milieu to treat neurological disorders. To overcome this, one of the… read more here.
Keywords: bbb; transcytosis; cell bbb; brain ... See more keywords