Reducing Senescent Cell Burden in Aging and Disease.
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DOI: 10.1016/j.molmed.2020.03.005
Abstract: Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical… read more here.
Keywords: medicine; senescent; cell burden; senescent cell ... See more keywords