CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215474119
Abstract: Significance We found that the immunoregulatory receptor CTLA-4 is expressed on mTECs, where it mediates T cell central tolerance. This work deepens our understanding of how T cell tolerance is established and autoimmunity can arise… read more here.
Keywords: thymic epithelial; cell central; ctla thymic; tolerance ... See more keywords
Analysis of a miR-148a Targetome in B Cell Central Tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861655
Abstract: A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of… read more here.
Keywords: cell central; mir 148a; target genes; central tolerance ... See more keywords