Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Investigations"
DOI: 10.1080/08820139.2020.1748047
Abstract: ABSTRACT Background: T cells present in chronic inflammatory tissues such as nasal polyps (from chronic rhinosinusitis patients) have been demonstrated to be hypo-responsive to activation via the TCR, similar to tumor-specific T cells in multiple… read more here.
Keywords: tumor; cell checkpoint; inflammatory; chronic inflammatory ... See more keywords
TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0811-x
Abstract: Tumors that lack pre-existing immune infiltration respond poorly to T cell checkpoint blockade immunotherapy. These cancers often surround themselves with high densities of suppressive myeloid stroma while excluding immunostimulatory dendritic cells. Tumor-resident myeloid cells and… read more here.
Keywords: checkpoint blockade; melanoma; cell checkpoint; blockade ... See more keywords