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   Articles with "cell chromatin" as a keyword



Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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recommendations! Published in 2021 at "Immunity"

DOI: 10.1016/j.immuni.2021.03.007

Abstract: Summary Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine… read more here.

Keywords: single cell; treg cells; tissue; chromatin accessibility ... See more keywords

Single-cell chromatin state analysis with Signac.

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recommendations! Published in 2021 at "Nature methods"

DOI: 10.1038/s41592-021-01282-5

Abstract: The recent development of experimental methods for measuring chromatin state at single-cell resolution has created a need for computational tools capable of analyzing these datasets. Here we developed Signac, a comprehensive toolkit for the analysis… read more here.

Keywords: single cell; signac; analysis; cell chromatin ... See more keywords

EpiCarousel: memory- and time-efficient identification of metacells for atlas-level single-cell chromatin accessibility data

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recommendations! Published in 2024 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btae191

Abstract: Abstract Summary Recent technical advancements in single-cell chromatin accessibility sequencing (scCAS) have brought new insights to the characterization of epigenetic heterogeneity. As single-cell genomics experiments scale up to hundreds of thousands of cells, the demand… read more here.

Keywords: time; cell chromatin; single cell; chromatin accessibility ... See more keywords

Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adk4694

Abstract: Cardiac regeneration requires coordinated participation of multiple cell types whereby their communications result in transient activation of proregenerative cell states. Although the molecular characteristics and lineage origins of these activated cell states and their contribution… read more here.

Keywords: cell chromatin; single cell; cell; cardiac regeneration ... See more keywords

ChromoGen: Diffusion model predicts single-cell chromatin conformations

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adr8265

Abstract: Breakthroughs in high-throughput sequencing and microscopic imaging technologies have revealed that chromatin structures vary considerably between cells of the same type. However, a thorough characterization of this heterogeneity remains elusive due to the labor-intensive and… read more here.

Keywords: chromatin conformations; cell chromatin; single cell; chromatin ... See more keywords

Single-cell chromatin and RNA analysis

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recommendations! Published in 2018 at "Science"

DOI: 10.1126/science.361.6409.1350-b

Abstract: Single-Cell Genomics Single-cell analyses have begun to provide insight into the differences among and within the individual cells that make up a tissue or organism. However, technological barriers owing to the small amount of material… read more here.

Keywords: single cell; rna analysis; chromatin rna; cell chromatin ... See more keywords

Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood.2023023237

Abstract: Key Points • Our results illustrate a complex and dynamic pattern of epigenetic and transcriptomic modifications in early PC genesis.• Preplasmablasts already undergo epigenetic remodeling related to mature PC together with unfolded protein response priming… read more here.

Keywords: cell chromatin; single cell; cell; integrative single ... See more keywords

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data

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recommendations! Published in 2020 at "Genome Biology"

DOI: 10.1186/s13059-020-02008-0

Abstract: Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-source software for comprehensive processing, analysis, and visualization of such data generated using… read more here.

Keywords: single cell; scatac pro; chromatin accessibility; accessibility sequencing ... See more keywords

The single-cell chromatin accessibility landscape in mouse perinatal testis development

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recommendations! Published in 2023 at "eLife"

DOI: 10.7554/elife.75624

Abstract: Spermatogenesis depends on an orchestrated series of developing events in germ cells and full maturation of the somatic microenvironment. To date, the majority of efforts to study cellular heterogeneity in testis has been focused on… read more here.

Keywords: cell chromatin; cell; accessibility; testis ... See more keywords