Reliable Detection of T-Cell Clonality by Flow Cytometry in Mature T-Cell Neoplasms Using TRBC1: Implementation as a Reflex Test and Comparison with PCR-Based Clonality Testing.
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory medicine"
DOI: 10.1093/labmed/lmac014
Abstract: OBJECTIVE The T-cell receptor β constant region 1 (TRBC1) antibody can identify T-cell clonality and distinguish pathological from normal T cells. This study aims to establish optimal cutpoints for establishing monotypia and validate the diagnostic… read more here.
Keywords: cell; flow cytometry; cell clonality; reflex test ... See more keywords
T‐cell clonality testing for the diagnosis of T‐cell large granular lymphocytic leukemia: Are we identifying pathology or incidental clones?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13949
Abstract: T‐cell clonality testing by T‐cell receptor (TCR) gene rearrangement is key to the diagnosis of T‐cell lymphoproliferative disorders such as T‐cell large granular lymphocytic (T‐LGL) leukemia. Benign clonal T‐cell expansions, however, are commonly found in… read more here.
Keywords: cell; cell clonality; pathology; diagnosis cell ... See more keywords
Diagnostic utility of the lymphoid screening tube supplemented with TRBC1 for the assessment of T-cell clonality.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14045
Abstract: INTRODUCTION Flow cytometric panels for the investigation of lymphoproliferative disorders, such as the EuroFlow Lymphoid Screening Tube (LST), often fail to demonstrate T-cell clonality, as a suitable clonality marker was unavailable until recently. Aim of… read more here.
Keywords: cell; cell clonality; analysis; clonality ... See more keywords
T cell clonality assessment: past, present and future
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DOI: 10.1136/jclinpath-2017-204761
Abstract: T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including… read more here.
Keywords: cell clonality; assessment past; pathology; clonality assessment ... See more keywords
Molecular Diagnosis of T-cell Lymphoma: A correlative study of PCR-based T-cell clonality assessment and targeted NGS.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2021005249
Abstract: Immunomorphological diagnosis of T-cell lymphomas (TCL) may be challenging, especially on needle biopsies. Multiplex polymerase chain reaction (PCR) assays to assess T-cell receptor (TCR) gene rearrangements are now widely used to detect T-cell clones and… read more here.
Keywords: diagnosis cell; diagnosis; cell clonality; pcr ... See more keywords
Anti-TRBC1 Antibody-Based Flow Cytometric Detection of T-Cell Clonality: Standardization of Sample Preparation and Diagnostic Implementation
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DOI: 10.3390/cancers13174379
Abstract: Simple Summary The anti-TRBC1 antibody JOVI-1 has recently been identified as a flow cytometry marker potentially useful for assessment of T-cell clonality. The aim of this study was to optimize a flow cytometric method for… read more here.
Keywords: cell clonality; antibody; trbc1; cell ... See more keywords
High-Sensitive TRBC1-Based Flow Cytometric Assessment of T-Cell Clonality in Tαβ-Large Granular Lymphocytic Leukemia
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DOI: 10.3390/cancers14020408
Abstract: Simple Summary TRBC1 expression analysis by flow cytometry (FCM) has been recently proved to be a useful, simple and fast approach to assessing Tαβ-cell clonality. The aim of this study was to validate the utility… read more here.
Keywords: large granular; trbc1 cells; trbc1; cell clonality ... See more keywords