Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02642-4
Abstract: Understanding of the functional states and clonal dynamics of T cells after immune checkpoint blockade (ICB) is valuable for improving these therapeutic strategies. Here we performed Smart-seq2 single-cell RNA sequencing (scRNA-seq) analysis on 3,110 peripheral… read more here.
Keywords: cell clones; small cell; non small; cancer ... See more keywords
Intrathecally Expanding B Cell Clones in Herpes Simplex Encephalitis: A Case Report
Sign Up to like & getrecommendations! Published in 2022 at "Neurology and Therapy"
DOI: 10.1007/s40120-022-00330-2
Abstract: Introduction In spite of antiviral treatment, herpes simplex encephalitis (HSE) remains associated with a poor prognosis and often results in neurological impairment. The B cell response in HSE is poorly understood. The objective of this… read more here.
Keywords: herpes simplex; time; cell; simplex encephalitis ... See more keywords
Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa790
Abstract: OBJECTIVES To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development. METHODS Next-generation sequencing of… read more here.
Keywords: highly expanded; clinical onset; cell clones; disease ... See more keywords
Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00568-21
Abstract: HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division. ABSTRACT Little is known about the emergence and persistence of human immunodeficiency… read more here.
Keywords: hiv infected; hiv; cell clones; integration ... See more keywords
SAT0005 DETECTION OF HIGHLY EXPANDED T CELL CLONES IN THE PERIPHERAL BLOOD OF AT RISK INDIVIDUALS FOR RHEUMATOID ARTHRITIS BEFORE THE CLINICAL ONSET OF THE DISEASE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4102
Abstract: Background: Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiopathogenesis. Systemic autoimmunity precedes clinical disease onset, and current evidence suggests that the immune onset of RA takes place outside of the joints several years… read more here.
Keywords: none declared; fdr; cell clones; group ... See more keywords
Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003325
Abstract: Background Sentinel lymph nodes (LNs) are regarded as key immune surveillance sites in cancer wherein mature dendritic cells present tumor-derived antigens to prime and activate T cells, which then migrate to the tumor site. However,… read more here.
Keywords: cell clones; cell; cancer; sentinel lns ... See more keywords
The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-3845
Abstract: Purpose: During our efforts to develop tumor-infiltrating lymphocyte (TIL) therapy to counter the devastating recurrence rate in patients with primary resectable pancreatic ductal adenocarcinoma (PDA), we found that PDA TILs can readily be expanded in… read more here.
Keywords: repertoire; cell clones; til; tumor ... See more keywords
The role of CD8+ T cell clones in immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018380
Abstract: Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease. However, a number of features suggest alternative mechanisms of platelet destruction. In this study, we use a multi-dimensional approach to explore the role of cytotoxic CD8+… read more here.
Keywords: cell clones; cell; immune thrombocytopenia; cd8 cells ... See more keywords
Establishment of Cytotoxic and Non-cytotoxic NK-92 Cell Clones – Evaluation of Their Function as Target Cells
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15925
Abstract: Background/Aim: Previous studies have demonstrated that NK cells present in PBMCs might explain why clinical trials conducted with NK-92 as well as CAR modified NK-92 cells have to a large extent failed. Two NK-92 clones… read more here.
Keywords: cell clones; target; cytotoxic; target cells ... See more keywords
KIR3DS1-Mediated Recognition of HLA-*B51: Modulation of KIR3DS1 Responsiveness by Self HLA-B Allotypes and Effect on NK Cell Licensing
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00581
Abstract: Several studies described an association between killer-cell immunoglobulin-like receptor (KIR)/HLA gene combinations and clinical outcomes in various diseases. In particular, an important combined role for KIR3DS1 and HLA-B Bw4-I80 in controlling viral infections and a… read more here.
Keywords: kir3ds1; cell clones; recognition hla; hla ... See more keywords
In rheumatoid arthritis inflamed joints share dominant patient-specific B-cell clones
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.915687
Abstract: Background In patients with rheumatoid arthritis (RA) different joints were shown to share the same dominant T-cell clones, suggesting shared characteristics of the inflammatory process and indicating that strategies to selectively target the antigen receptor… read more here.
Keywords: cell clones; cell; share dominant; different joints ... See more keywords