Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0070
Abstract: Cancer cells are known to have larger nucleoli, consistent with their higher transcriptional and translational demands. Meanwhile, on stiff extracellular matrix, normal epithelial cells can exhibit genomic and proteomic mechanoactivation toward tumorigenic transformations, such as… read more here.
Keywords: cell; epithelial cell; mechanical cues; cell collectives ... See more keywords
Enhanced mechanical heterogeneity of cell collectives due to temporal fluctuations in cell elasticity.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.107.014401
Abstract: Cells are dynamic systems characterized by temporal variations in biophysical properties such as stiffness and contractility. Recent studies show that the recruitment and release of actin filaments into and out of the cell cortex-a network… read more here.
Keywords: cell; mechanical heterogeneity; cell collectives; cell elasticity ... See more keywords
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Endocrinology and Metabolism"
DOI: 10.1152/ajpendo.00165.2022
Abstract: The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca2+ concentration ([Ca2+]c). To trigger exocytosis, Ca2+ ions enter the cytosol from intracellular Ca2+ stores or from the extracellular space. The… read more here.
Keywords: ca2 events; cell collectives; high resolution; cytosolic ca2 ... See more keywords